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All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping

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Title
All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping
Author(s)
Lee, Jung Min; Lin, Dingchang; Kim, Ha-Reem; Pyo, Young-Woo; Hong, Guosong; Lieber, Charles M.; Hong-Gyu Park
Publication Date
2021-04
Journal
Nano Letters, v.21, no.7, pp.3184 - 3190
Publisher
American Chemical Society
Abstract
The development of a multifunctional device that achieves optogenetic neuromodulation and extracellular neural mapping is crucial for understanding neural circuits and treating brain disorders. Although various devices have been explored for this purpose, it is challenging to develop biocompatible optogenetic devices that can seamlessly interface with the brain. Herein, we present a tissue-like optoelectronic mesh with a compact interface that enables not only high spatial and temporal resolutions of optical stimulation but also the sampling of optically evoked neural activities. An in vitro experiment in hydrogel showed efficient light propagation through a freestanding SU-8 waveguide that was integrated with flexible mesh electronics. Additionally, an in vivo implantation of the tissue-like optoelectronic mesh in the brain of a live transgenic mouse enabled the sampling of optically evoked neural signals. Therefore, this multifunctional device can aid the chronic modulation of neural circuits and behavior studies for developing biological and therapeutic applications.
URI
https://pr.ibs.re.kr/handle/8788114/9745
DOI
10.1021/acs.nanolett.1c00425
ISSN
1530-6984
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > 1. Journal Papers (저널논문)
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