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Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage

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Title
Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage
Author(s)
Ahn, So Yoon; Jie, Hyesoo; Won-Beom Jung; Jeong, Ji-Hyun; Ko, Sukjin; Geun Ho Im; Park, Won Soon; Jung Hee Lee; Chang, Yun Sil; Chung, Seungsoo
Publication Date
2021-08
Journal
EXPERIMENTAL NEUROLOGY, v.342
Publisher
Academic Press Inc.
Abstract
© 2021 Elsevier Inc.Severe neonatal intraventricular hemorrhage (IVH) patients incur long-term neurologic deficits such as cognitive disabilities. Recently, the intraventricular transplantation of allogeneic human umbilical cord blood-derived mesenchymal stem cells (MSCs) has drawn attention as a therapeutic potential to treat severe IVH. However, its pathological synaptic mechanism is still elusive. We here demonstrated that the integration of the somatosensory input was significantly distorted by suppressing feed-forward inhibition (FFI) at the thalamocortical (TC) inputs in the barrel cortices of neonatal rats with IVH by using BOLD-fMRI signal and brain slice patch-clamp technique. This is induced by the suppression of Hebbian plasticity via an increase in tumor necrosis factor-α expression during the critical period, which can be effectively reversed by the transplantation of MSCs. Furthermore, we showed that MSC transplantation successfully rescued IVH-induced learning deficits in the sensory-guided decision-making in correlation with TC FFI in the layer 4 barrel cortex.
URI
https://pr.ibs.re.kr/handle/8788114/9714
DOI
10.1016/j.expneurol.2021.113736
ISSN
0014-4886
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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