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Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage

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dc.contributor.authorAhn, So Yoon-
dc.contributor.authorJie, Hyesoo-
dc.contributor.authorWon-Beom Jung-
dc.contributor.authorJeong, Ji-Hyun-
dc.contributor.authorKo, Sukjin-
dc.contributor.authorGeun Ho Im-
dc.contributor.authorPark, Won Soon-
dc.contributor.authorJung Hee Lee-
dc.contributor.authorChang, Yun Sil-
dc.contributor.authorChung, Seungsoo-
dc.date.accessioned2021-05-31T01:50:02Z-
dc.date.accessioned2021-05-31T01:50:03Z-
dc.date.available2021-05-31T01:50:02Z-
dc.date.available2021-05-31T01:50:03Z-
dc.date.created2021-05-27-
dc.date.issued2021-08-
dc.identifier.issn0014-4886-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9714-
dc.description.abstract© 2021 Elsevier Inc.Severe neonatal intraventricular hemorrhage (IVH) patients incur long-term neurologic deficits such as cognitive disabilities. Recently, the intraventricular transplantation of allogeneic human umbilical cord blood-derived mesenchymal stem cells (MSCs) has drawn attention as a therapeutic potential to treat severe IVH. However, its pathological synaptic mechanism is still elusive. We here demonstrated that the integration of the somatosensory input was significantly distorted by suppressing feed-forward inhibition (FFI) at the thalamocortical (TC) inputs in the barrel cortices of neonatal rats with IVH by using BOLD-fMRI signal and brain slice patch-clamp technique. This is induced by the suppression of Hebbian plasticity via an increase in tumor necrosis factor-α expression during the critical period, which can be effectively reversed by the transplantation of MSCs. Furthermore, we showed that MSC transplantation successfully rescued IVH-induced learning deficits in the sensory-guided decision-making in correlation with TC FFI in the layer 4 barrel cortex.-
dc.language영어-
dc.publisherAcademic Press Inc.-
dc.titleStem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000663728100007-
dc.identifier.scopusid2-s2.0-85105806124-
dc.identifier.rimsid75705-
dc.contributor.affiliatedAuthorWon-Beom Jung-
dc.contributor.affiliatedAuthorGeun Ho Im-
dc.contributor.affiliatedAuthorJung Hee Lee-
dc.identifier.doi10.1016/j.expneurol.2021.113736-
dc.identifier.bibliographicCitationEXPERIMENTAL NEUROLOGY, v.342-
dc.relation.isPartOfEXPERIMENTAL NEUROLOGY-
dc.citation.titleEXPERIMENTAL NEUROLOGY-
dc.citation.volume342-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordPlusCHOICE-RELATED ACTIVITY-
dc.subject.keywordPlusHYDROCEPHALIC HTX-RATS-
dc.subject.keywordPlusCRITICAL-PERIOD-
dc.subject.keywordPlusBARREL CORTEX-
dc.subject.keywordPlusSENSORY PERCEPTION-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusSYNAPSES-
dc.subject.keywordPlusINTERNEURONS-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordAuthorIntraventricular hemorrhage-
dc.subject.keywordAuthorMesenchymal stem cell-
dc.subject.keywordAuthorThalamocortical input-
dc.subject.keywordAuthorFunctional MRI (fMRI)-
dc.subject.keywordAuthorBarrel cortex-
dc.subject.keywordAuthorSensory-guided decision making-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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