BROWSE

Related Scientist

CNIR's photo.

CNIR
뇌과학 이미징 연구단
more info

ITEM VIEW & DOWNLOAD

Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage

Cited 0 time in webofscience Cited 0 time in scopus
59 Viewed 0 Downloaded
Title
Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage
Author(s)
Ahn, So Yoon; Jie, Hyesoo; Won-Beom Jung; Jeong, Ji-Hyun; Ko, Sukjin; Geun Ho Im; Park, Won Soon; Jung Hee Lee; Chang, Yun Sil; Chung, Seungsoo
Publication Date
2021-08
Journal
EXPERIMENTAL NEUROLOGY, v.342
Publisher
Academic Press Inc.
Abstract
© 2021 Elsevier Inc.Severe neonatal intraventricular hemorrhage (IVH) patients incur long-term neurologic deficits such as cognitive disabilities. Recently, the intraventricular transplantation of allogeneic human umbilical cord blood-derived mesenchymal stem cells (MSCs) has drawn attention as a therapeutic potential to treat severe IVH. However, its pathological synaptic mechanism is still elusive. We here demonstrated that the integration of the somatosensory input was significantly distorted by suppressing feed-forward inhibition (FFI) at the thalamocortical (TC) inputs in the barrel cortices of neonatal rats with IVH by using BOLD-fMRI signal and brain slice patch-clamp technique. This is induced by the suppression of Hebbian plasticity via an increase in tumor necrosis factor-α expression during the critical period, which can be effectively reversed by the transplantation of MSCs. Furthermore, we showed that MSC transplantation successfully rescued IVH-induced learning deficits in the sensory-guided decision-making in correlation with TC FFI in the layer 4 barrel cortex.
URI
https://pr.ibs.re.kr/handle/8788114/9714
DOI
10.1016/j.expneurol.2021.113736
ISSN
0014-4886
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse