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King, John T.
첨단연성물질 연구단
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Phase separation of DNA: from past to present

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Title
Phase separation of DNA: from past to present
Author(s)
John T. King; Anisha Shakya
Publication Date
2021-04
Journal
Biophysical Journal, v.120, no.7, pp.1139 - 1149
Publisher
Biophysical Society
Abstract
Phase separation of biological molecules, such as nucleic acids and proteins, has garnered widespread attention across many fields in recent years. For instance, liquid-liquid phase separation has been implicated not only in membraneless intracellular organization but also in many biochemical processes, including transcription, translation, and cellular signaling. Here, we present a historical background of biological phase separation and survey current work on nuclear organization and its connection to DNA phase separation from the perspective of DNA sequence, structure, and genomic context. © 2021 Biophysical SocietyPhase separation of biological molecules, such as nucleic acids and proteins, has garnered widespread attention across many fields in recent years. For instance, liquid-liquid phase separation has been implicated not only in membraneless intracellular organization but also in many biochemical processes, including transcription, translation, and cellular signaling. Here, we present a historical background of biological phase separation and survey current work on nuclear organization and its connection to DNA phase separation from the perspective of DNA sequence, structure, and genomic context.
URI
https://pr.ibs.re.kr/handle/8788114/9507
DOI
10.1016/j.bpj.2021.01.033
ISSN
0006-3495
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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