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Anisha, Shakya
첨단연성물질 연구단
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Modern optical microscopy methods to study biomolecular condensates

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Title
Modern optical microscopy methods to study biomolecular condensates
Author(s)
Anisha Shakya; John T. King
Publication Date
2021-04
Journal
Current Opinion in Colloid and Interface Science, v.52
Publisher
Elsevier Ltd
Abstract
© 2021 Elsevier LtdCells achieve highly intricate internal organization via membrane-bound and membraneless organelles. Research over the past decade has implicated liquid–liquid phase separation, a phenomenon by which charged and often disordered biological macromolecules assemble into reversible liquid-like condensates, as the mechanism of formation of membraneless organelles in cells. During the same period, optical microscopy saw exciting advancements, including the super-resolution revolution, that were quickly adopted by researchers in the biological community. Today, there exists a vast library of techniques capable of providing unprecedented information regarding the formation, function, and dynamics of biomolecular condensates. In this review, we discuss a select number of modern optical microscopy methods that are particularly suited for studying biomolecular condensates both in vitro and in cells, as well as the associated technical challenges.
URI
https://pr.ibs.re.kr/handle/8788114/9506
DOI
10.1016/j.cocis.2021.101421
ISSN
1359-0294
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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