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Optical transfer function of time-gated coherent imaging in the presence of a scattering medium

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Title
Optical transfer function of time-gated coherent imaging in the presence of a scattering medium
Author(s)
PILSUNG KANG; SUNGSAM KANG; YONGHYEON JO; HAKSEOK KO; KIM, GUANGHOON; YE-RYOUNG LEE; WONSHIK CHOI
Subject
TURBID MEDIA, ; LIGHT, ; PHOTONS, ; DEEP
Publication Date
2021-02-01
Journal
OPTICS EXPRESS, v.29, no.3, pp.3395 - 3405
Publisher
OPTICAL SOC AMER
Abstract
Optical imaging of objects embedded within scattering media such as biological tissues suffers from the loss of resolving power. In our previous work, we proposed an approach called collective accumulation of single scattering (CASS) microscopy that attenuates this detrimental effect of multiple light scattering by combining the time-gated detection and spatial input-output correlation. In the present work, we perform a rigorous theoretical analysis on the effect of multiple light scattering to the optical transfer function of CASS microscopy. In particular, the spatial frequency-dependent signal to noise ratio (SNR) is derived depending on the intensity ratio of the single- and multiple-scattered waves. This allows us to determine the depth-dependent resolving power. We conducted experiments using a Siemens star-like target having various spatial frequency components and supported the theoretical derived SNR spectra. Our study provides a theoretical framework for understanding the effect of multiple light scattering in high-resolution and deep-tissue optical imaging (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
URI
https://pr.ibs.re.kr/handle/8788114/9209
DOI
10.1364/OE.412988
ISSN
1094-4087
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > 1. Journal Papers (저널논문)
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