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Osteoconductive hybrid hyaluronic acid hydrogel patch for effective bone formation

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Title
Osteoconductive hybrid hyaluronic acid hydrogel patch for effective bone formation
Author(s)
Soojeong Choi; Jong Seung Lee; Jisoo Shin; Min Suk Lee; Donyoung Kang; Nathaniel S. Hwang; Hyungsuk Lee; Hee Seok Yang; Seung-Woo Cho
Publication Date
2020-11
Journal
JOURNAL OF CONTROLLED RELEASE, v.327, pp.571 - 583
Publisher
ELSEVIER
Abstract
Bio-inspired adhesive hydrogels have been applied to cell and drug delivery systems to address various tissue defects and disorders. However, adhesive hydrogels functionalized with phenolic moieties often lack osteoconductive capacity and mechanical properties for bone regeneration. In this study, we utilized the versatile chemical interactions of phenolic moieties to overcome such limitations in bone tissue engineering efforts. Highly osteoconductive hybrid hydrogel patches were fabricated by incorporating inorganic minerals, hydroxyapatite (HAP), or whitlockite (WKT), into pyrogallol-conjugated hyaluronic acid (HA-PG). The hybrid HA-PG patches exhibited improved mechanical strength and reinforced structural/physical properties owing to additional intermolecular complexation between oxidized PG moieties and ions released from inorganic particles. The sustained release of bone morphogenetic protein-2 (BMP-2) from hybrid patches was prolonged by combination of the inherent nucleophilic affinity of oxidized PG and electrostatic interactions between inorganic particles and BMP-2. With increased osteoconductivity, hybrid patches with HAP or WKT enhanced the osteogenic differentiation of human stem cells while also promoting new bone formation in a critical-sized calvarial defect. Our study demonstrates a translational potential of phenolic adhesive hydrogels engineered with inorganic minerals for orthopedic applications.
URI
https://pr.ibs.re.kr/handle/8788114/9123
DOI
10.1016/j.jconrel.2020.09.006
ISSN
0168-3659
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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