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Lee, Hyunsoo
나노물질 및 화학반응 연구단
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Troponin Aptamer on an Atomically Flat Au Nanoplate Platform for Detection of Cardiac Troponin I

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Title
Troponin Aptamer on an Atomically Flat Au Nanoplate Platform for Detection of Cardiac Troponin I
Author(s)
Hyoban Lee; Hyungjun Youn; Ahreum Hwang; Hyunsoo Lee; Jeong Young Park; Weon Kim; Youngdong Yoo; Changill Ban; Taejoon Kang; Bongsoo Kim
Publication Date
2020-07
Journal
NANOMATERIALS, v.10, no.7, pp.1402
Publisher
MDPI
Abstract
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Well-ordered bioreceptors on atomically flat Au surfaces can be a high-performance biosensor. Cardiac troponin I proteins (cTnIs) have been regarded as a specific biomarker for acute myocardial infarction (AMI). Here, we report the accurate detection of cTnIs using an aptamer-immobilized Au nanoplate platform. The single-crystalline and atomically flat Au nanoplate was characterized by atomic force microscopy. For the precise detection of cTnI, we immobilized an aptamer that can strongly bind to cTnI onto an atomically flat Au nanoplate. Using the aptamer-immobilized Au nanoplate, cTnIs were successfully detected at a concentration of 100 aM (2.4 fg/mL) in buffer solution. Furthermore, cTnIs in serum could be identified at a concentration of 100 fM (2.4 pg/mL). The total assay time was similar to 7 h. Importantly, the aptamer-immobilized Au nanoplate enabled us to diagnose AMI patients accurately, suggesting the potential of the present method in the diagnosis of AMI
URI
https://pr.ibs.re.kr/handle/8788114/9055
DOI
10.3390/nano10071402
ISSN
2079-4991
Appears in Collections:
Center for Nanomaterials and Chemical Reactions(나노물질 및 화학반응 연구단) > 1. Journal Papers (저널논문)
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