BROWSE

Related Scientist

William, Pineros's photo.

William, Pineros
첨단연성물질 연구단
more info

ITEM VIEW & DOWNLOAD

Kinetic proofreading and the limits of thermodynamic uncertainty

Cited 0 time in webofscience Cited 0 time in scopus
8 Viewed 0 Downloaded
Title
Kinetic proofreading and the limits of thermodynamic uncertainty
Author(s)
William D. Piñeros; Tsvi Tlusty
Publication Date
2020-02
Journal
PHYSICAL REVIEW E, v.101, no.2, pp.1 - 8
Publisher
AMER PHYSICAL SOC
Abstract
To mitigate errors induced by the cell's heterogeneous noisy environment, its main information channels and production networks utilize the kinetic proofreading (KPR) mechanism. Here, we examine two extensively studied KPR circuits, DNA replication by the T7 DNA polymerase and translation by the E. coli ribosome. Using experimental data, we analyze the performance of these two vital systems in light of the fundamental bounds set by the recently discovered thermodynamic uncertainty relation (TUR), which places an inherent trade-off between the precision of a desirable output and the amount of energy dissipation required. We show that the DNA polymerase operates close to the TUR lower bound, while the ribosome operates similar to 5 times farther from this bound. This difference originates from the enhanced binding discrimination of the polymerase which allows it to operate effectively as a reduced reaction cycle prioritizing correct product formation. We show that approaching this limit also decouples the thermodynamic uncertainty factor from speed and error, thereby relaxing the accuracy-speed trade-off of the system. Altogether, our results show that operating near this reduced cycle limit not only minimizes thermodynamic uncertainty, but also results in global performance enhancement of KPR circuits
URI
https://pr.ibs.re.kr/handle/8788114/9004
DOI
10.1103/PhysRevE.101.022415
ISSN
2470-0045
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse