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Grzybowski, Bartosz Andrzej
첨단연성물질 연구단
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Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry

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Title
Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry
Author(s)
Agnieszka Wołos; Rafał Roszak; Anna Żądło-Dobrowolska; Wiktor Beker; Barbara Mikulak-Klucznik; Grzegorz Spólnik; Mirosław Dygas; Sara Szymkuć; Bartosz A. Grzybowski
Publication Date
2020-09
Journal
Science, v.369, no.6511, pp.1 - 12
Publisher
American Association for the Advancement of Science
Abstract
The challenge of prebiotic chemistry is to trace the syntheses of life's key building blocks from a handful of primordial substrates. Here we report a forward-synthesis algorithm that generates a full network of prebiotic chemical reactions accessible from these substrates under generally accepted conditions. This network contains both reported and previously unidentified routes to biotic targets, as well as plausible syntheses of abiotic molecules. It also exhibits three forms of nontrivial chemical emergence, as the molecules within the network can act as catalysts of downstream reaction types; form functional chemical systems, including self-regenerating cycles; and produce surfactants relevant to primitive forms of biological compartmentalization. To support these claims, computer-predicted, prebiotic syntheses of several biotic molecules as well as a multistep, self-regenerative cycle of iminodiacetic acid were validated by experiment
URI
https://pr.ibs.re.kr/handle/8788114/8998
DOI
10.1126/science.aaw1955
ISSN
0036-8075
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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