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Lee, Seong Sin
식물 노화·수명 연구단
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The core circadian component, Bmal1, is maintained in the pineal gland of old killifish brain

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Title
The core circadian component, Bmal1, is maintained in the pineal gland of old killifish brain
Author(s)
Seong Sin Lee; Hong Gil Nam; Yu mi Kim
Publication Date
2021-01
Journal
Iscience, v.24, no.1, pp.101905
Publisher
CELL PRESS
Abstract
Circadian rhythm is altered during aging, although the underlying molecular mechanisms remain largely unknown. Here, we used the turquoise killifish as a short-lived vertebrate model to examine the effects of aging on the major circadian network comprising the four mammalian clock protein homologs, Bmal1, Clockb, Cry1b, and Per3, which are highly conserved in the killifish with 50%– 85% amino acid sequence identity to their human counterparts. The amplitude of circadian rhythmwas smaller in old fish (14 weeks) than in young fish (6 weeks). In old fish brain, the Bmal1 protein level was significantly downregulated. However, the Bmal1 interaction with Clockb and chromatin binding of Bmal1 to its downstream target promoters were retained. Furthermore, Bmal1 was relatively well maintained in the pineal gland compared with other regions of the old fish brain. The results suggest that the circadian clock system in the killifish becomes spatially confined to the pineal gland upon aging.
URI
https://pr.ibs.re.kr/handle/8788114/8934
DOI
10.1016/j.isci.2020.101905
ISSN
2589-0042
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > 1. Journal Papers (저널논문)
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