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Lee, ChangJoon Justin
인지 및 사회성 연구단
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Serial optical coherence microscopy for label-free volumetric histopathology

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Title
Serial optical coherence microscopy for label-free volumetric histopathology
Author(s)
Min E.; Ban S.; Lee J.; Vavilin A.; Baek S.; Jung S.; Ahn Y.; Park K.; Shin S.; Han S.H.; Cho H.; Lee-Kwon W.; Kim J.; ChangJoon Justin Lee; Jung W.
Subject
SINGLE-CELL RESOLUTION, ; BRAIN, ; TOMOGRAPHY, ; TISSUES
Publication Date
2020-04
Journal
SCIENTIFIC REPORTS, v.10, no.1, pp.6711
Publisher
NATURE PUBLISHING GROUP
Abstract
© 2020, The Author(s). The observation of histopathology using optical microscope is an essential procedure for examination of tissue biopsies or surgically excised specimens in biological and clinical laboratories. However, slide-based microscopic pathology is not suitable for visualizing the large-scale tissue and native 3D organ structure due to its sampling limitation and shallow imaging depth. Here, we demonstrate serial optical coherence microscopy (SOCM) technique that offers label-free, high-throughput, and large-volume imaging of ex vivo mouse organs. A 3D histopathology of whole mouse brain and kidney including blood vessel structure is reconstructed by deep tissue optical imaging in serial sectioning techniques. Our results demonstrate that SOCM has unique advantages as it can visualize both native 3D structures and quantitative regional volume without introduction of any contrast agents
URI
https://pr.ibs.re.kr/handle/8788114/8681
DOI
10.1038/s41598-020-63460-3
ISSN
2045-2322
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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