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Chemical Controllable Gene Drive in Drosophila

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Title
Chemical Controllable Gene Drive in Drosophila
Author(s)
Dongwoo Chae; Junwon Lee; Nayoung Lee; Kyungsoo Park; Seok Jun Moon; Hyongbum H. Kim
Subject
CRISPR-Cas9 system, ; gene drive, ; mutagenic chain reaction, ; population genetics, ; Rippase
Publication Date
2020-09
Journal
ACS SYNTHETIC BIOLOGY, v.9, no.9, pp.2362 - 2377
Publisher
AMER CHEMICAL SOC
Abstract
© 2020 American Chemical Society. Gene drive systems that propagate transgenes via super-Mendelian inheritance can potentially control insect-borne diseases and agricultural pests. However, concerns have been raised regarding unforeseen ecological consequences, and methods that prevent undesirable gene drive effects have been proposed. Here, we report a chemical-induced control of gene drive. We prepared a CRISPR-based gene drive system that can be removed by a site-specific recombinase, Rippase, the expression of which is induced by the chemical RU486 in fruit flies. Exposure of fruit flies to RU486 resulted in 7-12% removal of gene drive elements at each generation, leading to a significant reduction in gene drive-fly propagation. Mathematical modeling and simulation suggest that our system offers several advantages over a previously reported gene drive control system. Our chemical control system can provide a proof-of-principle for the reversible control of gene drive effects depending on ecological status and human needs
URI
https://pr.ibs.re.kr/handle/8788114/8479
DOI
10.1021/acssynbio.0c00117
ISSN
2161-5063
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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