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Facile fabrication and application of near-IR light-responsive drug release system based on gold nanorods and phase change material

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Title
Facile fabrication and application of near-IR light-responsive drug release system based on gold nanorods and phase change material
Author(s)
Junseok Lee; Cherlhyun Jeong; Won Jong Kim
Publication Date
2014-12
Journal
JOURNAL OF MATERIALS CHEMISTRY B, v.2, no.47, pp.8338 - 8345
Publisher
ROYAL SOC CHEMISTRYROYAL SOC CHEMISTRY
Abstract
Near-IR (NIR)-responsive drug delivery systems have received enormous attention because of their good biocompatibility and the high biological penetration of NIR. This work describes the facile fabrication and anticancer effect of a NIR-responsive drug delivery system based on the nano-assembly of mesoporous silica-coated gold nanorods (AuNR@mSiO2) and a phase change material (PCM). The core gold nanorods in AuNR@mSiO2 provided excellent NIR sensitivity, and the mesoporous silica shell provided an increased reservoir of loaded drug. The PCM was applied as both a thermosensitive gatekeeper and a medium for a hydrophobic anticancer drug. The photothermal effect of the AuNRs under NIR irradiation facilitated a rapid release of the drug through the temperature-sensitive phase transition of PCM at just above body temperature. An enhanced anticancer effect was observed against various cell lines, and intracellular release of the drug was easily monitored by live cell imaging. Our system does not require any complicated synthetic methods for fabrication, and PCM is easily capable of solubilizing various hydrophobic drugs. Therefore, this system has significant potential for broad application in the biomedical field as a delivery system for hydrophobic drugs with NIR-responsive behavior.
URI
https://pr.ibs.re.kr/handle/8788114/847
ISSN
2050-750X
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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