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Extracellular matrixes and neuroinflammation

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Title
Extracellular matrixes and neuroinflammation
Author(s)
Dong Gil Jang; Hyo Jung Sim; Eun Kyung Song; Taejoon Kwon; Tae Joo Park
Subject
DAMP, ; Extracellular matrix, ; Neurodegenerative disease and ECM, ; Neuroinflammation, ; Neuronal ECM
Publication Date
2020-11
Journal
BMB REPORTS, v.53, no.10, pp.491 - 499
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Abstract
© Korean Society for Biochemistry and Molecular Biology. The extracellular matrix is a critical component of every human tissue. ECM not only functions as a structural component but also regulates a variety of cellular processes such as cell migration, differentiation, proliferation, and cell death. In addition, current studies suggest that ECM is critical for the pathophysiology of various human diseases. ECM is composed of diverse components including several proteins and polysaccharide chains such as chondroitin sulfate, heparan sulfate, and hyaluronic acid. Each component of ECM exerts its own functions in cellular and pathophysiological processes. One of the interesting recent findings is that ECM is involved in inflammatory responses in various human tissues. In this review, we summarized the known functions of ECM in neuroinflammation after acute injury and chronic inflammatory diseases of the central nerve systems.
URI
https://pr.ibs.re.kr/handle/8788114/8449
DOI
10.5483/bmbrep.2020.53.10.156
ISSN
1976-6696
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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