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Time-gated iterative phase conjugation for efficient light energy delivery in scattering media

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Title
Time-gated iterative phase conjugation for efficient light energy delivery in scattering media
Author(s)
DONG-YOUNG KIM; SEUNGWON JEONG; MOOSEOK JANG; YE-RYOUNG LEE; WONSHIK CHOI
Subject
Digital micromirror devices, ; Light propagation, ; Multiple scattering, ; Phase conjugation, ; Scattering media, ; Wave propagation
Publication Date
2020-03
Journal
Optics Express, v.28, no.5, pp.7382 - 7391
Publisher
OSA Publishing
Abstract
© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.Light waves propagating through complex biological tissues are spatially spread by multiple light scattering, and this spread limits the working depth in optical bioimaging, phototherapy, and optogenetics. Here, we propose the iterative phase conjugation of time-gated backscattered waves for enhancing the light energy delivered to a target object embedded in a scattering medium. We demonstrate the enhancement of light energy delivered to a target object hidden behind a 200-μm-thick mouse skull by more than ten times in comparison with the initial random input. The maximum enhancement was reached in only 10 iterations, more than a hundred times smaller than existing methods based on either a time-gated reflection matrix or iterative feedback optimization of the time-gated reflection intensity. Consequently, the proposed method is less sensitive to sample perturbations. Furthermore, the number of images required for optimization remained almost unchanged with an increase in the illumination area, unlike existing methods, where the convergence time scales with the illumination area. The proposed method provides high operation speed over a wide illumination area, which can facilitate the use of wavefront shaping in practical applications Journal © 2020
URI
https://pr.ibs.re.kr/handle/8788114/8331
DOI
10.1364/OE.385557
ISSN
1094-4087
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > 1. Journal Papers (저널논문)
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