BROWSE

Related Scientist

Researcher

양보기
면역 미생물 공생 연구단
more info

Negative role of inducible PD-1 on survival of activated dendritic cells

Cited 11 time in webofscience Cited 0 time in scopus
364 Viewed 28 Downloaded
Title
Negative role of inducible PD-1 on survival of activated dendritic cells
Author(s)
Seong Jeong Park; Hong Namkoong; Junsang Doh; Jong-Cheol Choi; Bo-Gie Yang; Yunji Park; Young Chul Sung
Publication Date
2014-04
Journal
JOURNAL OF LEUKOCYTE BIOLOGY, v.95, no.4, pp.621 - 629
Publisher
FEDERATION AMER SOC EXP BIOL
Abstract
PD-1 is a well-established negative regulator of T cell responses by inhibiting proliferation and cytokine production of T cells via interaction with its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), expressed on non-T cells. Recently, PD-1 was found to be expressed in innate cells, including activated DCs, and plays roles in suppressing production of inflammatory cytokines. In this study, we demonstrate that PD-1 KO DCs exhibited prolonged longevity compared with WT DCs in the dLNs after transfer of DCs into hind footpads. Interestingly, upon LPS stimulation, WT DCs increased the expression of PD-1 and started to undergo apoptosis. DCs, in spleen of LPS-injected PD-1 KO mice, were more resistant to LPS-mediated apoptosis in vivo than WT controls. Moreover, treatment of blocking anti-PD-1 mAb during DC maturation resulted in enhanced DC survival, suggesting that PD-1: PD-L interactions are involved in DC apoptosis. As a result, PD-1-deficient DCs augmented T cell responses in terms of antigen-specific IFN- production and proliferation of CD4 and CD8 T cells to a greater degree than WT DCs. Moreover, PD-1 KO DCs exhibited increased MAPK1 and CD40–CD40L signaling, suggesting a possible mechanism for enhanced DC survival in the absence of PD-1 expression. Taken together, our findings further extend the function of PD-1, which plays an important role in apoptosis of activated DCs and provides important implications for PD-1-mediated immune regulation. J. Leukoc. Biol. 95: 621–629; 2014.
URI
https://pr.ibs.re.kr/handle/8788114/793
ISSN
0741-5400
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Files in This Item:
첨부7. Negative role of inducible PD-1 on survival of activated dendritic cells.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse