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Negative role of inducible PD-1 on survival of activated dendritic cells

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dc.contributor.authorSeong Jeong Park-
dc.contributor.authorHong Namkoong-
dc.contributor.authorJunsang Doh-
dc.contributor.authorJong-Cheol Choi-
dc.contributor.authorBo-Gie Yang-
dc.contributor.authorYunji Park-
dc.contributor.authorYoung Chul Sung-
dc.date.available2015-04-19T10:57:45Z-
dc.date.created2014-08-11-
dc.date.issued2014-04-
dc.identifier.issn0741-5400-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/793-
dc.description.abstractPD-1 is a well-established negative regulator of T cell responses by inhibiting proliferation and cytokine production of T cells via interaction with its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), expressed on non-T cells. Recently, PD-1 was found to be expressed in innate cells, including activated DCs, and plays roles in suppressing production of inflammatory cytokines. In this study, we demonstrate that PD-1 KO DCs exhibited prolonged longevity compared with WT DCs in the dLNs after transfer of DCs into hind footpads. Interestingly, upon LPS stimulation, WT DCs increased the expression of PD-1 and started to undergo apoptosis. DCs, in spleen of LPS-injected PD-1 KO mice, were more resistant to LPS-mediated apoptosis in vivo than WT controls. Moreover, treatment of blocking anti-PD-1 mAb during DC maturation resulted in enhanced DC survival, suggesting that PD-1: PD-L interactions are involved in DC apoptosis. As a result, PD-1-deficient DCs augmented T cell responses in terms of antigen-specific IFN- production and proliferation of CD4 and CD8 T cells to a greater degree than WT DCs. Moreover, PD-1 KO DCs exhibited increased MAPK1 and CD40–CD40L signaling, suggesting a possible mechanism for enhanced DC survival in the absence of PD-1 expression. Taken together, our findings further extend the function of PD-1, which plays an important role in apoptosis of activated DCs and provides important implications for PD-1-mediated immune regulation. J. Leukoc. Biol. 95: 621–629; 2014.-
dc.language영어-
dc.publisherFEDERATION AMER SOC EXP BIOL-
dc.titleNegative role of inducible PD-1 on survival of activated dendritic cells-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000335346300007-
dc.identifier.scopusid2-s2.0-84899865906-
dc.identifier.rimsid250ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorBo-Gie Yang-
dc.identifier.doi10.1189/jlb.0813443-
dc.identifier.bibliographicCitationJOURNAL OF LEUKOCYTE BIOLOGY, v.95, no.4, pp.621 - 629-
dc.relation.isPartOfJOURNAL OF LEUKOCYTE BIOLOGY-
dc.citation.titleJOURNAL OF LEUKOCYTE BIOLOGY-
dc.citation.volume95-
dc.citation.number4-
dc.citation.startPage621-
dc.citation.endPage629-
dc.date.scptcdate2018-10-01-
dc.description.wostc11-
dc.description.scptc10-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordAuthorApoptosis-
dc.subject.keywordAuthorImmune regulator-
dc.subject.keywordAuthorInhibitory-
dc.subject.keywordAuthorLPS-
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Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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