Negative role of inducible PD-1 on survival of activated dendritic cells
DC Field | Value | Language |
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dc.contributor.author | Seong Jeong Park | - |
dc.contributor.author | Hong Namkoong | - |
dc.contributor.author | Junsang Doh | - |
dc.contributor.author | Jong-Cheol Choi | - |
dc.contributor.author | Bo-Gie Yang | - |
dc.contributor.author | Yunji Park | - |
dc.contributor.author | Young Chul Sung | - |
dc.date.available | 2015-04-19T10:57:45Z | - |
dc.date.created | 2014-08-11 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/793 | - |
dc.description.abstract | PD-1 is a well-established negative regulator of T cell responses by inhibiting proliferation and cytokine production of T cells via interaction with its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), expressed on non-T cells. Recently, PD-1 was found to be expressed in innate cells, including activated DCs, and plays roles in suppressing production of inflammatory cytokines. In this study, we demonstrate that PD-1 KO DCs exhibited prolonged longevity compared with WT DCs in the dLNs after transfer of DCs into hind footpads. Interestingly, upon LPS stimulation, WT DCs increased the expression of PD-1 and started to undergo apoptosis. DCs, in spleen of LPS-injected PD-1 KO mice, were more resistant to LPS-mediated apoptosis in vivo than WT controls. Moreover, treatment of blocking anti-PD-1 mAb during DC maturation resulted in enhanced DC survival, suggesting that PD-1: PD-L interactions are involved in DC apoptosis. As a result, PD-1-deficient DCs augmented T cell responses in terms of antigen-specific IFN- production and proliferation of CD4 and CD8 T cells to a greater degree than WT DCs. Moreover, PD-1 KO DCs exhibited increased MAPK1 and CD40–CD40L signaling, suggesting a possible mechanism for enhanced DC survival in the absence of PD-1 expression. Taken together, our findings further extend the function of PD-1, which plays an important role in apoptosis of activated DCs and provides important implications for PD-1-mediated immune regulation. J. Leukoc. Biol. 95: 621–629; 2014. | - |
dc.language | 영어 | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.title | Negative role of inducible PD-1 on survival of activated dendritic cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000335346300007 | - |
dc.identifier.scopusid | 2-s2.0-84899865906 | - |
dc.identifier.rimsid | 250 | ko |
dc.date.tcdate | 2018-10-01 | - |
dc.contributor.affiliatedAuthor | Bo-Gie Yang | - |
dc.identifier.doi | 10.1189/jlb.0813443 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.95, no.4, pp.621 - 629 | - |
dc.relation.isPartOf | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 95 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 621 | - |
dc.citation.endPage | 629 | - |
dc.date.scptcdate | 2018-10-01 | - |
dc.description.wostc | 11 | - |
dc.description.scptc | 10 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Immune regulator | - |
dc.subject.keywordAuthor | Inhibitory | - |
dc.subject.keywordAuthor | LPS | - |