Hydrotrifluoromethylation and iodotrifluoromethylation of alkenes and alkynes using an inorganic electride as a radical generator
DC Field | Value | Language |
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dc.contributor.author | Sungkyu Choi | - |
dc.contributor.author | Ye Ji Kim | - |
dc.contributor.author | Sun Min Kim | - |
dc.contributor.author | Jung Woon Yang | - |
dc.contributor.author | Sung Wng Kim | - |
dc.contributor.author | Eun Jin Cho | - |
dc.date.available | 2015-04-19T10:57:38Z | - |
dc.date.created | 2014-11-26 | ko |
dc.date.issued | 2014-09 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/781 | - |
dc.description.abstract | The trifluoromethyl (CF3) group is a staple synthon that can alter the physical and chemical properties of organic molecules. Despite recent advances in trifluoromethylation methods, the development of a general synthetic methodology for efficient and selective trifluoromethylation remains an ongoing challenge motivated by a steadily increasing demand from the pharmaceutical, agrochemical and materials science industries. In this article, we describe a simple, efficient and environmentally benign strategy for the hydrotrifluoromethylation of unactivated alkenes and alkynes through a radical-mediated reaction using an inorganic electride, [Ca2N]þ e, as the electron source. In the transformation, anionic electrons are transferred from [Ca2N]þ e electrides to the trifluoromethylating reagent CF3I to initiate radical-mediated trifluoromethylation. The role of ethanol is pivotal in the transformation, acting as the solvent, an electron-releasing promoter and a hydrogen atom source. In addition, iodotrifluoromethylation of alkynes proceeds selectively upon the control of electride amount. | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Hydrotrifluoromethylation and iodotrifluoromethylation of alkenes and alkynes using an inorganic electride as a radical generator | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000342983300008 | - |
dc.identifier.scopusid | 2-s2.0-84923368588 | - |
dc.identifier.rimsid | 16555 | ko |
dc.date.tcdate | 2018-10-01 | - |
dc.contributor.affiliatedAuthor | Ye Ji Kim | - |
dc.contributor.affiliatedAuthor | Sung Wng Kim | - |
dc.identifier.doi | 10.1038/ncomms5881 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.5, pp.4881 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 5 | - |
dc.citation.startPage | 4881 | - |
dc.date.scptcdate | 2018-10-01 | - |
dc.description.wostc | 29 | - |
dc.description.scptc | 35 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |