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A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing

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Title
A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing
Author(s)
Sha Yu; V. Narry Kim
Subject
CYTOPLASMIC POLY(A) POLYMERASE, ; HISTONE MESSENGER-RNAS, ; QUALITY-CONTROL PATHWAY, ; PROTEIN QKI-7 RECRUITS, ; STRUCTURAL BASIS, ; 3&apos, ; END, ; SELECTIVE STABILIZATION, ; TRANSLATIONAL CONTROL, ; SURVEILLANCE PATHWAY, ; RIBOSOMAL-RNA
Publication Date
2020-09
Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY, v.21, no.9, pp.542 - 556
Publisher
NATURE PUBLISHING GROUP
Abstract
© 2020, Springer Nature Limited. RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most frequent and conserved type of RNA modification. The addition of tails and their composition reflect RNA maturation stages and have important roles in determining the fate of the modified RNAs. Apart from canonical poly(A) polymerases, which add poly(A) tails to mRNAs in a transcription-coupled manner, a family of terminal nucleotidyltransferases (TENTs), including terminal uridylyltransferases (TUTs), modify RNAs post-transcriptionally to control RNA stability and activity. The human genome encodes 11 different TENTs with distinct substrate specificity, intracellular localization and tissue distribution. In this Review, we discuss recent advances in our understanding of non-canonical RNA tails, with a focus on the functions of human TENTs, which include uridylation, mixed tailing and post-transcriptional polyadenylation of mRNAs, microRNAs and other types of non-coding RNA
URI
https://pr.ibs.re.kr/handle/8788114/7667
DOI
10.1038/s41580-020-0246-8
ISSN
1471-0072
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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