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A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing

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dc.contributor.authorSha Yu-
dc.contributor.authorV. Narry Kim-
dc.date.accessioned2020-12-22T02:47:15Z-
dc.date.accessioned2020-12-22T02:47:15Z-
dc.date.available2020-12-22T02:47:15Z-
dc.date.available2020-12-22T02:47:15Z-
dc.date.created2020-06-29-
dc.date.issued2020-09-
dc.identifier.issn1471-0072-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/7667-
dc.description.abstract© 2020, Springer Nature Limited. RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most frequent and conserved type of RNA modification. The addition of tails and their composition reflect RNA maturation stages and have important roles in determining the fate of the modified RNAs. Apart from canonical poly(A) polymerases, which add poly(A) tails to mRNAs in a transcription-coupled manner, a family of terminal nucleotidyltransferases (TENTs), including terminal uridylyltransferases (TUTs), modify RNAs post-transcriptionally to control RNA stability and activity. The human genome encodes 11 different TENTs with distinct substrate specificity, intracellular localization and tissue distribution. In this Review, we discuss recent advances in our understanding of non-canonical RNA tails, with a focus on the functions of human TENTs, which include uridylation, mixed tailing and post-transcriptional polyadenylation of mRNAs, microRNAs and other types of non-coding RNA-
dc.description.uri1-
dc.language영어-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectCYTOPLASMIC POLY(A) POLYMERASE-
dc.subjectHISTONE MESSENGER-RNAS-
dc.subjectQUALITY-CONTROL PATHWAY-
dc.subjectPROTEIN QKI-7 RECRUITS-
dc.subjectSTRUCTURAL BASIS-
dc.subject3&apos-
dc.subjectEND-
dc.subjectSELECTIVE STABILIZATION-
dc.subjectTRANSLATIONAL CONTROL-
dc.subjectSURVEILLANCE PATHWAY-
dc.subjectRIBOSOMAL-RNA-
dc.titleA tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000537031000002-
dc.identifier.scopusid2-s2.0-85085900574-
dc.identifier.rimsid72308-
dc.contributor.affiliatedAuthorSha Yu-
dc.contributor.affiliatedAuthorV. Narry Kim-
dc.identifier.doi10.1038/s41580-020-0246-8-
dc.identifier.bibliographicCitationNATURE REVIEWS MOLECULAR CELL BIOLOGY, v.21, no.9, pp.542 - 556-
dc.citation.titleNATURE REVIEWS MOLECULAR CELL BIOLOGY-
dc.citation.volume21-
dc.citation.number9-
dc.citation.startPage542-
dc.citation.endPage556-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusCYTOPLASMIC POLY(A) POLYMERASE-
dc.subject.keywordPlusHISTONE MESSENGER-RNAS-
dc.subject.keywordPlusQUALITY-CONTROL PATHWAY-
dc.subject.keywordPlusPROTEIN QKI-7 RECRUITS-
dc.subject.keywordPlusSTRUCTURAL BASIS-
dc.subject.keywordPlus3&apos-
dc.subject.keywordPlusEND-
dc.subject.keywordPlusSELECTIVE STABILIZATION-
dc.subject.keywordPlusTRANSLATIONAL CONTROL-
dc.subject.keywordPlusSURVEILLANCE PATHWAY-
dc.subject.keywordPlusRIBOSOMAL-RNA-
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Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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