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Lhee, Sangmoon
식물 노화·수명 연구단
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Spatial localization of charged molecules by salt ions in oil-confined water microdroplets

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Title
Spatial localization of charged molecules by salt ions in oil-confined water microdroplets
Author(s)
SangMoon Lhee; Jae Kyoo Lee; Jooyoun Kang; Shota Kato; Sunhee Kim; Richard N. Zare; Hong Gil Nam
Publication Date
2020-10
Journal
SCIENCE ADVANCES, v.6, no.41, pp.1 - 9
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Cells contain more than 100 mM salt ions that are typically confined to dimensions of 5 to 10 micrometers by a hydrophobic cellular membrane. We found that in aqueous microdroplets having the same size as cells and that are confined in hydrocarbon oil, negatively charged molecules were distributed rather uniformly over the interior of the microdroplet, whereas positively charged molecules were localized at and near the surface. However, the addition of salt (NaCl) to the microdroplet caused all charged molecules to be localized near the oil-water interface. This salt-induced relocalization required less salt concentration in microdroplets compared to bulk water. Moreover, the localization became more prominent as the size of the microdroplet was reduced. The relocatization also critically depended on the type of oil. Our results imply that salt ions and different hydrophobic interfaces together may govern the local distribution of charged biomolecules in confined intracellular environments
URI
https://pr.ibs.re.kr/handle/8788114/7594
DOI
10.1126/sciadv.aba0181
ISSN
2375-2548
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > 1. Journal Papers (저널논문)
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