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Myung, Kyung Jae
유전체 항상성 연구단
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Exploring the role of a novel peptide from allomyrina dichotoma larvae in ameliorating lipid metabolism in obesity

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Title
Exploring the role of a novel peptide from allomyrina dichotoma larvae in ameliorating lipid metabolism in obesity
Author(s)
Sung Mun Bae; Meiqi Fan; Young-Jin Choi; Yujiao Tang; Gwanghui Jeong; Kyungjae Myung; Byung-gyu Kim; Eun-Kyung Kim
Publication Date
2020-11
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.22, pp.8537
Publisher
MDPI AG
Abstract
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The aim of this study was to identify an anti-obesity peptide from Allomyrina dichotoma and investigate the lipid metabolic mechanism. Enzymatically hydrolyzed A. dichotoma larvae were further separated using tangential flow filtration and consecutive chromatographic processes. Finally, an anti-obesity peptide that showed the highest inhibitory effect on lipid accumulation was obtained, and the sequence was Glu-Ile-Ala-Gln-Asp-Phe-Lys-Thr-Asp-Leu (EIA10). EIA10 decreased lipid aggregation in vitro and significantly reduced the accumulation of body weight gain, liver weight, and adipose tissue weight in high-fat-fed mice. Compared with the control group, the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL), insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) in the high-fat diet (HFD) group increased significantly, and the content of high-density lipoprotein cholesterol (HDL) in the serum decreased significantly. On the contrary, the levels of TC, TG, and insulin in the EIA10 group decreased significantly, and the HDL content increased significantly compared with the HFD group. Additionally, EIA10 dramatically decreased mRNA and protein levels of transcription factors involved in lipid adipogenesis. Taken together, our results suggest that EIA10 could be a promising agent for the treatment and prevention of obesity
URI
https://pr.ibs.re.kr/handle/8788114/7552
DOI
10.3390/ijms21228537
ISSN
1661-6596
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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