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Kim, Seong Gi
뇌과학 이미징 연구단
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Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses: GABAergic neurons initiate functional hyperemia

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Title
Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses: GABAergic neurons initiate functional hyperemia
Author(s)
Alexander John Poplawsky; Bistra Iordanova; Alberto L. Vazquez; Seong-Gi Kim; Mitsuhiro Fukuda
Publication Date
2021-01
Journal
NEUROIMAGE, v.225, no.15
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Abstract
Functional MRI responses are localized to the synaptic sites of evoked inhibitory neurons, but it is unknown whether, or by what mechanisms, these neurons initiate functional hyperemia. Here, the neuronal origins of these hemodynamic responses were investigated by fMRI or local field potential and blood flow measurements during topical application of pharmacological agents when GABAergic granule cells in the rat olfactory bulb were synaptically targeted. First, to examine if postsynaptic activation of these inhibitory neurons was required for neurovascular coupling, we applied an NMDA receptor antagonist during cerebral blood volume-weighted fMRI acquisition and found that responses below the drug application site (up to ~1.5 mm) significantly decreased within ~30 min. Similarly, large decreases in granule cell postsynaptic activities and blood flow responses were observed when AMPA or NMDA receptor antagonists were applied. Second, inhibition of nitric oxide synthase preferentially decreased the initial, fast component of the blood flow response, while inhibitors of astrocyte-specific glutamate transporters and vasoactive intestinal peptide receptors did not decrease blood flow responses. Third, inhibition of GABA release with a presynaptic GABAB receptor agonist caused less reduction of neuronal and blood flow responses compared to the postsynaptic glutamate receptor antagonists. In conclusion, local hyperemia by synaptically-evoked inhibitory neurons was primarily driven by their postsynaptic activities, possibly through NMDA receptor-dependent calcium signaling that was not wholly dependent on nitric oxide
URI
https://pr.ibs.re.kr/handle/8788114/7500
DOI
10.1016/j.neuroimage.2020.117457
ISSN
1053-8119
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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