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Rapid three‐dimensional steady‐state chemical exchange saturation transfer magnetic resonance imaging

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Title
Rapid three‐dimensional steady‐state chemical exchange saturation transfer magnetic resonance imaging
Author(s)
Hoonjae Lee; Seung Hong Choi; Chul‐Ho Sohn; Seong-Gi Kim; Joonyeol Lee; Jaeseok Park
Publication Date
2021-03
Journal
MAGNETIC RESONANCE IN MEDICINE, v.85, no.3, pp.1209 - 1221
Publisher
WILEY-BLACKWELL
Abstract
© 2020 International Society for Magnetic Resonance in Medicine. Purpose: To make clinically feasible whole-brain chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) by enhancing imaging efficiency. Methods: A novel, whole-brain three-dimensional (3D) steady-state CEST MRI method was introduced by utilizing a time-efficient, fat-suppressed excitation followed by rapid, segmented 3D echo-planar-imaging with incoherent undersampling in k-ω space. Missing signals and CEST-specific spectral images were then jointly estimated directly from incomplete measurements using model-based reconstruction and robust spectral analysis. In vivo studies were performed at 3T both retrospectively (using a fully sampled reference) and prospectively to validate the effectiveness of the proposed method in patients with brain cancer. Results: In retrospective studies, the proposed method exhibits superior accuracies to existing methods in estimating images, z-spectra, and APTw relative to the reference. In prospective patient studies, compared with existing methods, the proposed method is statistically significantly different in contrast-to-noise ratio of the APTw contrast between tumor and normal appearing white matter (NAWM) and amide proton transfer weighted contrast (p < 0.05) while not being significantly different in signal-to-noise ratio in an NAWM region. Conclusions: We successfully demonstrated that it is feasible to perform wholebrain CEST MRI roughly within 4 minutes for patients with brain cancer. It is expected that the proposed method widens clinical utilities of CEST MRI.
URI
https://pr.ibs.re.kr/handle/8788114/7494
DOI
10.1002/mrm.28487
ISSN
0740-3194
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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