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뇌과학이미징연구단
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Rapid three‐dimensional steady‐state chemical exchange saturation transfer magnetic resonance imaging

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dc.contributor.authorHoonjae Lee-
dc.contributor.authorSeung Hong Choi-
dc.contributor.authorChul‐Ho Sohn-
dc.contributor.authorSeong-Gi Kim-
dc.contributor.authorJoonyeol Lee-
dc.contributor.authorJaeseok Park-
dc.date.accessioned2020-12-22T02:20:20Z-
dc.date.accessioned2020-12-22T02:20:20Z-
dc.date.available2020-12-22T02:20:20Z-
dc.date.available2020-12-22T02:20:20Z-
dc.date.created2020-12-07-
dc.date.issued2021-03-
dc.identifier.issn0740-3194-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/7494-
dc.description.abstract© 2020 International Society for Magnetic Resonance in Medicine. Purpose: To make clinically feasible whole-brain chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) by enhancing imaging efficiency. Methods: A novel, whole-brain three-dimensional (3D) steady-state CEST MRI method was introduced by utilizing a time-efficient, fat-suppressed excitation followed by rapid, segmented 3D echo-planar-imaging with incoherent undersampling in k-ω space. Missing signals and CEST-specific spectral images were then jointly estimated directly from incomplete measurements using model-based reconstruction and robust spectral analysis. In vivo studies were performed at 3T both retrospectively (using a fully sampled reference) and prospectively to validate the effectiveness of the proposed method in patients with brain cancer. Results: In retrospective studies, the proposed method exhibits superior accuracies to existing methods in estimating images, z-spectra, and APTw relative to the reference. In prospective patient studies, compared with existing methods, the proposed method is statistically significantly different in contrast-to-noise ratio of the APTw contrast between tumor and normal appearing white matter (NAWM) and amide proton transfer weighted contrast (p < 0.05) while not being significantly different in signal-to-noise ratio in an NAWM region. Conclusions: We successfully demonstrated that it is feasible to perform wholebrain CEST MRI roughly within 4 minutes for patients with brain cancer. It is expected that the proposed method widens clinical utilities of CEST MRI.-
dc.description.uri1-
dc.language영어-
dc.publisherJohn Wiley & Sons Inc.-
dc.titleRapid three‐dimensional steady‐state chemical exchange saturation transfer magnetic resonance imaging-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000562774400001-
dc.identifier.scopusid2-s2.0-85089865067-
dc.identifier.rimsid73967-
dc.contributor.affiliatedAuthorHoonjae Lee-
dc.contributor.affiliatedAuthorSeong-Gi Kim-
dc.contributor.affiliatedAuthorJoonyeol Lee-
dc.identifier.doi10.1002/mrm.28487-
dc.identifier.bibliographicCitationMagnetic Resonance in Medicine, v.85, no.3, pp.1209 - 1221-
dc.citation.titleMagnetic Resonance in Medicine-
dc.citation.volume85-
dc.citation.number3-
dc.citation.startPage1209-
dc.citation.endPage1221-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.subject.keywordAuthorsteady-state CEST MRI-
dc.subject.keywordAuthoramide proton transfer-
dc.subject.keywordAuthorchemical exchange saturation transfer-
dc.subject.keywordAuthorfast imaging-
dc.subject.keywordAuthormagnetic resonance imaging-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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