BROWSE

Related Scientist

aim's photo.

aim
면역미생물공생연구단
more info

ITEM VIEW & DOWNLOAD

Protective effects of Fc-fused PD-L1 on two different animal models of colitis

DC Field Value Language
dc.contributor.authorSong, M.Y.-
dc.contributor.authorChun-Pyo Hong-
dc.contributor.authorPark, S.J.-
dc.contributor.authorJung-Hwan Kim-
dc.contributor.authorBo-Gie Yang-
dc.contributor.authorPark, Y.-
dc.contributor.authorKim, S.W.-
dc.contributor.authorKwang Soon Kim-
dc.contributor.authorLee, J.Y.-
dc.contributor.authorLee, S.W.-
dc.contributor.authorMyoung Ho Jang-
dc.contributor.authorSung, Y.C.-
dc.date.available2015-04-19T10:56:57Z-
dc.date.created2014-08-11-
dc.date.issued2015-01-
dc.identifier.issn0017-5749-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/745-
dc.description.abstractObjective Programmed death-ligand 1 (PD-L1) has been shown to negatively regulate immune responses via its interaction with PD-1 receptor. In this study, we investigated the effects of PD-L1-Fc treatment on intestinal inflammation using two murine models of inflammatory colitis induced by dextran sulfate sodium (DSS) and T-cell transfer. Design The anti-colitis effect of adenovirus expressing Fc-conjugated PD-L1 (Ad/PD-L1-Fc) and recombinant PD-L1-Fc protein was evaluated in DSS-treated wild-type and Rag-1 knockout (KO) mice. We examined differentiation of T-helper cells, frequency of innate immune cells, and cytokine production by dendritic cells (DCs) in the colon from DSS-treated mice after PD-L1-Fc administration. In Rag-1 KO mice reconstituted with CD4 CD45RBhigh T cells, we assessed the treatment effect of PD-L1-Fc protein on the development of colitis. Results Administration of Ad/PD-L1-Fc significantly ameliorated DSS-induced colitis, which was accompanied by diminished frequency of interleukin (IL)-17Aproducing CD4 T cells and increased interferon-γ- producing CD4 T cells in the colon of DSS-fed mice. The anti-colitic effect of PD-L1-Fc treatment was also observed in DSS-treated Rag-1 KO mice, indicating lymphoid cell independency. PD-L1-Fc modulated cytokine production by colonic DCs and the effect was dependent on PD-1 expression. Furthermore, PD-L1-Fc protein could significantly reduce the severity of colitis in CD4 CD45RBhigh T-cell-transferred Rag-1 KO mice. Conclusions Based on the protective effect of PD-L1- Fc against DSS-induced and T-cell-induced colitis, our results suggest that PD-1-mediated inhibitory signals have a crucial role in limiting the development of colonic inflammation. This implicates that PD-L1-Fc may provide a novel therapeutic approach to treat inflammatory bowel disease.-
dc.description.uri1-
dc.language영어-
dc.publisherB M J PUBLISHING GROUP-
dc.titleProtective effects of Fc-fused PD-L1 on two different animal models of colitis-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000348449800013-
dc.identifier.scopusid2-s2.0-84920873268-
dc.identifier.rimsid252ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorChun-Pyo Hong-
dc.contributor.affiliatedAuthorJung-Hwan Kim-
dc.contributor.affiliatedAuthorBo-Gie Yang-
dc.contributor.affiliatedAuthorKwang Soon Kim-
dc.contributor.affiliatedAuthorMyoung Ho Jang-
dc.identifier.doi10.1136/gutjnl-2014-307311-
dc.identifier.bibliographicCitationGUT, v.64, no.2, pp.260 - 271-
dc.citation.titleGUT-
dc.citation.volume64-
dc.citation.number2-
dc.citation.startPage260-
dc.citation.endPage271-
dc.date.scptcdate2018-10-01-
dc.description.wostc15-
dc.description.scptc14-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusINFLAMMATORY-BOWEL-DISEASE-
dc.subject.keywordPlusINTESTINAL LAMINA PROPRIA-
dc.subject.keywordPlusDSS-INDUCED COLITIS-
dc.subject.keywordPlusT-CELL RESPONSES-
dc.subject.keywordPlusDENDRITIC CELLS-
dc.subject.keywordPlusULCERATIVE-COLITIS-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlusINNATE-
dc.subject.keywordPlusMACROPHAGES-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
첨부6. Gut_protective effects of Fc-fused PD_L1 on two different animal models of colitis.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse