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Magnetic Control of Axon Navigation in Reprogrammed Neurons

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Title
Magnetic Control of Axon Navigation in Reprogrammed Neurons
Author(s)
Yoonhee Jin; Jung-uk Lee; Eunna Chung; Kisuk Yang; Jin Kim; Ji-wook Kim; Jong Seung Lee; Ann-Na Cho; Taekyu Oh; Jae-Hyun Lee; Seung-Woo Cho; Jinwoo Cheon
Publication Date
2019-09
Journal
NANO LETTERS, v.19, no.9, pp.6517 - 6523
Publisher
AMER CHEMICAL SOC
Abstract
While neural cell transplantation represents a promising therapy for neurodegenerative diseases, the formation of functional networks of transplanted cells with host neurons constitutes one of the challenging steps. Here, we introduce a magnetic guidance methodology that controls neurite growth signaling via magnetic nanoparticles (MNPs) conjugated with antibodies targeting the deleted in colorectal cancer (DCC) receptor (DCC-MNPs). Activation of the DCC receptors by clusterization and subsequent axonal growth of the induced neuronal (iN) cells was performed in a spatially controlled manner. In addition to the directionality of the magnetically controlled axon projection, axonal growth of the iN cells assisted the formation of functional connections with pre-existing primary neurons. Our results suggest magnetic guidance as a strategy for improving neuronal connectivity by spatially guiding the axonal projections of transplanted neural cells for synaptic interactions with the host tissue
URI
https://pr.ibs.re.kr/handle/8788114/6890
ISSN
1530-6984
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > Journal Papers
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