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Jonathan Sabate Del Rio
첨단연성물질 연구단
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An antifouling coating that enables affinity-based electrochemical biosensing in complex biological fluids

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Title
An antifouling coating that enables affinity-based electrochemical biosensing in complex biological fluids
Author(s)
Jonathan Sabaté del Río; Olivier Y. F. Henry; Jolly P.; Ingber D.E.
Publication Date
2019-12
Journal
NATURE NANOTECHNOLOGY, v.14, no.12, pp.1143 - 1149
Publisher
NATURE PUBLISHING GROUP
Abstract
© 2019, The Author(s), under exclusive licence to Springer Nature Limited.Affinity-based electrochemical detection in complex biological fluids could enable multiplexed point-of-care diagnostics for home healthcare; however, commercialization of point-of-care devices has been limited by the rapid loss of sensitivity caused by electrode surface inactivation and biofouling. Here, we describe a simple and robust antifouling coating for electrodes consisting of a three-dimensional porous matrix of cross-linked bovine serum albumin supported by a network of conductive nanomaterials composed of either gold nanowires, gold nanoparticles or carbon nanotubes. These nanocomposites prevent non-specific interactions while enhancing electron transfer to the electrode surface, preserving 88% of the original signal after 1 month of exposure to unprocessed human plasma, and functionalization with specific antibodies enables quantification of anti-interleukin 6 in plasma with high sensitivity. The easy preparation, stability and simplicity of this nanocomposite allow the generation of electrochemical biosensors that can operate in complex biological fluids such as blood plasma or serum
URI
https://pr.ibs.re.kr/handle/8788114/6753
ISSN
1748-3387
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
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