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나노의학 연구단
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Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent

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Title
Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent
Author(s)
Sang Bong Lee; Ye Ri Han; Hui-Jeon Jeon; Chul-Ho Jun; Sang-Kyoon Kim; Jungwook Chin; Su-Jeong Lee; Minseon Jeong; Jae-Eon Lee; Chang-Hee Lee; Sung Jin Cho; Dong-Su Kim; Yong Hyun Jeon
Publication Date
2019-12
Journal
JOURNAL OF MATERIALS CHEMISTRY B, v.7, no.46, pp.7326 - 7331
Publisher
ROYAL SOC CHEMISTRY
Abstract
© 2019 The Royal Society of Chemistry.Structure-based targeting of fluorescent dyes is essential for their use as imaging agents for disease diagnosis. Here, we describe the development of the benzoquinolizinium compound Medical fluorophore 1 (MF1) as a novel biomedical imaging agent that allows the visualization of inflammation by virtue of its unique chemical structure. Lipopolysaccharide treatment stimulated the uptake of MF1 by bone marrow-derived macrophages, with no adverse effects on cell proliferation. In vivo fluorescence lifetime imaging revealed the accumulation of MF1 in carrageenan-induced acute inflammatory lesions in mice, which peaked at 6 h. MF1-based imaging also allowed monitoring of the response to the anti-inflammatory drugs dexamethasone and sulfasalazine. Thus, MF1 can be used to diagnose diseases characterized by inflammation as well as treatment efficacy
URI
https://pr.ibs.re.kr/handle/8788114/6740
ISSN
2050-750X
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > Journal Papers
Files in This Item:
201912_Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent.pdfDownload

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