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Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis TreatmentHighly Cited Paper

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dc.contributor.authorJonghoon Kim-
dc.contributor.authorKim H.Y.-
dc.contributor.authorSong S.Y.-
dc.contributor.authorGo S.-H.-
dc.contributor.authorSohn H.S.-
dc.contributor.authorSeungmin Baik-
dc.contributor.authorMin Soh-
dc.contributor.authorKang Kim-
dc.contributor.authorKim D.-
dc.contributor.authorKim H.-C.-
dc.contributor.authorLee N.-
dc.contributor.authorKim B.-S.-
dc.contributor.authorTaeghwan Hyeon-
dc.date.available2019-11-13T07:34:04Z-
dc.date.created2019-04-23-
dc.date.issued2019-03-
dc.identifier.issn1936-0851-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/6481-
dc.description.abstractPoor O 2 supply to the infiltrated immune cells in the joint synovium of rheumatoid arthritis (RA) up-regulates hypoxia-inducible factor (HIF-1α) expression and induces reactive oxygen species (ROS) generation, both of which exacerbate synovial inflammation. Synovial inflammation in RA can be resolved by eliminating pro-inflammatory M1 macrophages and inducing anti-inflammatory M2 macrophages. Because hypoxia and ROS in the RA synovium play a crucial role in the induction of M1 macrophages and reduction of M2 macrophages, herein, we develop manganese ferrite and ceria nanoparticle-anchored mesoporous silica nanoparticles (MFC-MSNs) that can synergistically scavenge ROS and produce O 2 for reducing M1 macrophage levels and inducing M2 macrophages for RA treatment. MFC-MSNs exhibit a synergistic effect on O 2 generation and ROS scavenging that is attributed to the complementary reaction of ceria nanoparticles (NPs) that can scavenge intermediate hydroxyl radicals generated by manganese ferrite NPs in the process of O 2 generation during the Fenton reaction, leading to the efficient polarization of M1 to M2 macrophages both in vitro and in vivo. Intra-articular administration of MFC-MSNs to rat RA models alleviated hypoxia, inflammation, and pathological features in the joint. Furthermore, MSNs were used as a drug-delivery vehicle, releasing the anti-rheumatic drug methotrexate in a sustained manner to augment the therapeutic effect of MFC-MSNs. This study highlights the therapeutic potential of MFC-MSNs that simultaneously generate O 2 and scavenge ROS, subsequently driving inflammatory macrophages to the anti-inflammatory subtype for RA treatment. © 2019 American Chemical Society-
dc.description.uri1-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.subjectmacrophage polarization-
dc.subjectManganese ferrite nanoparticles-
dc.subjectnanomedicine-
dc.subjectoxygen generation-
dc.subjectrheumatoid arthritis-
dc.titleSynergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000462950500048-
dc.identifier.scopusid2-s2.0-85062830247-
dc.identifier.rimsid67920-
dc.contributor.affiliatedAuthorJonghoon Kim-
dc.contributor.affiliatedAuthorSeungmin Baik-
dc.contributor.affiliatedAuthorMin Soh-
dc.contributor.affiliatedAuthorKang Kim-
dc.contributor.affiliatedAuthorKim D.-
dc.contributor.affiliatedAuthorTaeghwan Hyeon-
dc.identifier.doi10.1021/acsnano.8b08785-
dc.identifier.bibliographicCitationACS NANO, v.13, no.3, pp.3206 - 3217-
dc.citation.titleACS NANO-
dc.citation.volume13-
dc.citation.number3-
dc.citation.startPage3206-
dc.citation.endPage3217-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusMESOPOROUS SILICA NANOPARTICLES-
dc.subject.keywordPlusTUMOR-ASSOCIATED MACROPHAGES-
dc.subject.keywordPlusPHOTODYNAMIC THERAPY-
dc.subject.keywordPlusCERIA NANOPARTICLES-
dc.subject.keywordPlusOXIDE NANOPARTICLES-
dc.subject.keywordPlusIN-SITU-
dc.subject.keywordPlusHYPOXIA-
dc.subject.keywordPlusPOLARIZATION-
dc.subject.keywordPlusHIF-1-ALPHA-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordAuthormanganese ferrite nanoparticles-
dc.subject.keywordAuthoroxygen generation-
dc.subject.keywordAuthormacrophage polarization-
dc.subject.keywordAuthorrheumatoid arthritis-
dc.subject.keywordAuthornanomedicine-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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