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분자활성 촉매반응 연구단
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Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C-H Amidation

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Title
Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C-H Amidation
Author(s)
Hoi-Yun Jung; Sukbok Chang; Sungwoo Hong
Publication Date
2019-09
Journal
ORGANIC LETTERS, v.21, no.17, pp.7099 - 7103
Publisher
AMER CHEMICAL SOC
Abstract
© 2019 American Chemical Society.A new approach has elaborated on the conversion of γ-lactones to the corresponding NH γ-lactams that can serve as γ-lactone bioisosteres. This approach consists of reductive C-O cleavage and an Ir-catalyzed C-H amidation, offering a powerful synthetic tool for accessing a wide range of valuable NH γ-lactam building blocks starting from γ-lactones. The synthetic utility was further demonstrated by the late-stage transformation of complex bioactive molecules and the asymmetric transformation
URI
https://pr.ibs.re.kr/handle/8788114/6435
ISSN
1523-7060
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
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