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Meng Li
복잡계 자기조립 연구단
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Cucurbit[7]uril-conjugated dyes as live cell imaging probes: Investigation on their cellular uptake and excretion pathways

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Title
Cucurbit[7]uril-conjugated dyes as live cell imaging probes: Investigation on their cellular uptake and excretion pathways
Author(s)
Meng Li; Lee A.; Kim S.; Annadka Shrinidhi; Kyeng Min Park; Kimoon Kim
Publication Date
2019-07
Journal
ORGANIC & BIOMOLECULAR CHEMISTRY, v.17, no.25, pp.6215 - 6220
Publisher
ROYAL SOC CHEMISTRY
Abstract
© 2019 The Royal Society of Chemistry.Here we report the endocytosis and excretion pathways of two different dye-conjugated cucurbit[7]urils, (cyanine 3-conjugated CB[7] and rhodamine X-conjugated CB[7]), which have great potential as molecular probes for live cell imaging. The dye-CB[7]s are translocated into live cells (human breast carcinoma cells, MCF-7) via multiple pathways, predominantly by clathrin-mediated endocytosis, and excreted from cells via lysosome-associated exocytosis. Interestingly, the CB[7] moiety has a substantial influence on the uptake and excretion pathways. These findings may widen the applications of the dyes conjugated to CB[7] and assist in the design of new molecular probes for live cell imaging
URI
https://pr.ibs.re.kr/handle/8788114/6373
ISSN
1477-0520
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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