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Sumit Kumar
첨단연성물질 연구단
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Human Platelet Membrane Functionalized Microchips with Plasmonic Codes for Cancer Detection

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Title
Human Platelet Membrane Functionalized Microchips with Plasmonic Codes for Cancer Detection
Author(s)
Sumit Kumar; Jae-A Han; Issac J. Michael; Ki D.; Vijaya Sunkara; Juhee Park; Shreedhar Gautam; Ha H.K.; Zhang L.; Yoon-Kyoung Cho
Publication Date
2019-07
Journal
ADVANCED FUNCTIONAL MATERIALS, v.29, no.30, pp.1902669 -
Publisher
WILEY-V C H VERLAG GMBH
Abstract
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimThe possibility of functional roles played by platelets in close alliance with cancer cells has inspired the design of new biomimetic systems that exploit platelet–cancer cell interactions. Here, the role of platelets in cancer diagnostics is leveraged to design a microfluidic platform capable of detecting cancer-derived extracellular vesicles (EVs) from ultrasmall volumes (1 µL) of human plasma samples. Further, the captured EVs are counted by direct optical coding of plasmonic nanoprobes modified with EV-specific antibodies. Owing to the inherent properties of platelets for multifaceted interaction with cancer cells, the microfluidic chip equipped with a biologically interfaced platelet membrane-cloaked surface (denoted “PLT-Chip”) can capture a significantly higher number of EVs from multiple types of cancer cell lines (prostate, lung, bladder, and breast) than the normal cell-derived EVs. Furthermore, this chip allows the monitoring of the growth of tumor spheroids (100 µm–2.5 mm) and clearly distinguishes the plasma of cancer patients from that of normal healthy controls. This robust, multifaceted, and cancer-specific binding affinity, coupled with excellent biocompatibility, is a unique feature of platelet membrane-cloaked surfaces, which therefore represent promising alternatives to antibodies for application in EVs-based cancer theranostics
URI
https://pr.ibs.re.kr/handle/8788114/6303
ISSN
1616-301X
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
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