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나노의학 연구단
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Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording

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Title
Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording
Author(s)
Yunlong Zhao; Anqi Zhang; Siheng Sean You; Jae-Hyun Lee; Jinlin Huang; Charles M. Lieber
Publication Date
2019-08
Journal
NATURE NANOTECHNOLOGY, v.14, no.8, pp.783 - +
Publisher
NATURE PUBLISHING GROUP
Abstract
© 2019, The Author(s), under exclusive licence to Springer Nature Limited.New tools for intracellular electrophysiology that push the limits of spatiotemporal resolution while reducing invasiveness could provide a deeper understanding of electrogenic cells and their networks in tissues, and push progress towards human–machine interfaces. Although significant advances have been made in developing nanodevices for intracellular probes, current approaches exhibit a trade-off between device scalability and recording amplitude. We address this challenge by combining deterministic shape-controlled nanowire transfer with spatially defined semiconductor-to-metal transformation to realize scalable nanowire field-effect transistor probe arrays with controllable tip geometry and sensor size, which enable recording of up to 100 mV intracellular action potentials from primary neurons. Systematic studies on neurons and cardiomyocytes show that controlling device curvature and sensor size is critical for achieving high-amplitude intracellular recordings. In addition, this device design allows for multiplexed recording from single cells and cell networks and could enable future investigations of dynamics in the brain and other tissues
URI
https://pr.ibs.re.kr/handle/8788114/6223
ISSN
1748-3387
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > Journal Papers
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201908_Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording_Jay-Hyun Lee.pdfDownload

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