BROWSE

Related Scientist

Researcher

유전체 항상성 연구단
유전체 항상성 연구단
more info

TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways

Cited 0 time in webofscience Cited 0 time in scopus
32 Viewed 8 Downloaded
Title
TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways
Author(s)
Han Y.G.; Yun M.; Choi M.; Lee S.-G.; Hongtae Kim
Publication Date
2019-06
Journal
ONCOLOGY REPORTS, v.41, no.6, pp.3305 - 3312
Publisher
SPANDIDOS PUBL LTD
Abstract
© 2019 Spandidos Publications. All rights reserved. Histone H2B monoubiquitination has been shown to play critical roles in diverse cellular processes including DNA damage response. Although recent data indicate that H2B monoubiquitination is strongly connected with tumor progression and regulation, the implications of this modification in lung adenocarcinoma are relatively unknown. In the present study, we demonstrated the clinical implication of H2B monoubiquitination and the potential role of tumor necrosis factor receptor-associated factor-interacting protein (TRAIP) in regulating its modification in lung adenocarcinoma. Immunohistochemical analysis showed that H2B monoubiquitination was significantly downregulated in 68 human lung adenocarcinoma patient samples compared to their normal adjacent tissues. Depletion of TRAIP by specific siRNA treatment markedly decreased ionizing radiation (IR)-induced H2B monoubiquitination. In addition, deletion mutants without RING domain or C-terminus of TRAIP diminished the ability to induce H2B monoubiquitination at lysine 120. Notably, the nuclear expression of TRAIP was positively related with H2B monoubiquitination levels in patients with lung adenocarcinoma. Furthermore, statistical analysis indicated that low levels of both TRAIP and H2B monoubiquitination, not each alone, in patients with lung adenocarcinoma were strongly correlated with poor survival. Taken together, these results suggest that TRAIP is a novel regulator of H2B monoubiquitination in DNA damage response and cancer development in lung adenocarcinoma
URI
https://pr.ibs.re.kr/handle/8788114/6150
ISSN
1021-335X
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > Journal Papers (저널논문)
Files in This Item:
Oncology Reports_2019_TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse