Immature dendritic cells navigate microscopic mazes to find tumor cells

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Title
Immature dendritic cells navigate microscopic mazes to find tumor cells
Author(s)
Eu Jin Um; Jung Min Oh; Juhee Park; Taegeun Song; Tae Eon Kim; Yongjun Choi; Chang Sik Shin; Diana Kolygina; Jae-Hyung Jeon; Bartosz A. Grzybowski; Yoon Kyoung Cho
Publication Date
2019-05
Journal
LAB ON A CHIP, v.19, no.9, pp.1665 - 1675
Publisher
ROYAL SOC CHEMISTRY
Abstract
Dendritic cells (DCs) are potent antigen-presenting cells with high sentinel ability to scan their neighborhood and to initiate an adaptive immune response. Whereas chemotactic migration of mature DCs (mDCs) towards lymph nodes is relatively well documented, the migratory behavior of immature DCs (imDCs) in tumor microenvironments is still poorly understood. Here, microfluidic systems of various geometries, including mazes, are used to investigate how the physical and chemical microenvironment influences the migration pattern of imDCs. Under proper degree of confinement, the imDCs are preferentially recruited towards cancer vs. normal cells, accompanied by increased cell speed and persistence. Furthermore, a systematic screen of cytokines, reveals that Gas6 is a major chemokine responsible for the chemotactic preference. These results and the accompanying theoretical model suggest that imDC migration in complex tissue environments is tuned by a proper balance between the strength of the chemical gradients and the degree of spatial confinement. © The Royal Society of Chemistry 2019
URI
https://pr.ibs.re.kr/handle/8788114/6073
ISSN
1473-0197
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
Files in This Item:
2019_Yoon_Lab.Chip._Immature dendritic cells navigate microscopic mazes to find tumor cells.pdfDownload

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