The role of mediodorsal thalamic nucleus in fear extinction

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Title
The role of mediodorsal thalamic nucleus in fear extinction
Author(s)
Sukchan Lee; Hee-Sup Shin
Publication Date
2016
Journal
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, v.7, no.13, pp. -
Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
Abstract
Understanding the neural mechanism underlying the formation and extinction of fear memory would guide the development of advanced strategies for treatment of post-traumatic stress disorder (PTSD), a generalized anxiety disorder. The mediodorsal thalamic nucleus (MD) is reciprocally connected with limbic circuitry including the prefrontal cortex and amygdala, key structures for fear formation, and extinction. In addition to the distinctive anatomical relationships, the MD participates in learning and memory process in fear extinction through thalamic dual firing modes: tonic and burst. This review will briefly describe neural mechanisms of fear extinction and highlight the role of MD in modulation of fear extinction. We suggest that excitability of the MD neurons may modulate fear circuits and can be a novel target for treatment of anxiety disorders.© 2016 Lee and Shin. Open Access
URI
https://pr.ibs.re.kr/handle/8788114/6037
ISSN
2093-3134
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Social Neuroscience Group(사회성 뇌과학 그룹) > Journal Papers (저널논문)
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