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Ravi Verma
면역 미생물 공생 연구단
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Bifidobacterium bifidum presents on the cell surface a complex mixture of glucans and galactans with different immunological properties

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Title
Bifidobacterium bifidum presents on the cell surface a complex mixture of glucans and galactans with different immunological properties
Author(s)
Immacolata Speciale; Ravi Verma; Flaviana Di Lorenzo; Antonio Molinaro; Sin-Hyeog Im; Cristina De Castro
Publication Date
2019-08
Journal
CARBOHYDRATE POLYMERS, v.218, no., pp.269 - 278
Publisher
ELSEVIER SCI LTD
Abstract
© 2019 Elsevier Ltd The chemical structure of cell surface polysaccharides isolated from Bifidobacterium bifidum strain PRI1, an important member of the gut microbiota of breast-fed infants, has been elucidated by chemical and NMR spectroscopy analysis. Results demonstrated that the bacterium produces a complex mixture of polysaccharides that could be classified in two main groups: a phospho-glycero-β-galactofuranan, PGβG, and a mixture composed of four neutral polysaccharides named as (CSGG), composed of β-(1 → 6)-glucan, β-(1 → 4)-galactan, β-(1 → 6)-galactan, β-galactofuranan and starch. These two fractions exerted different immune responses when assayed on dendritic cells: PGβG enhanced pro-inflammatory immune responses by increasing interferon-γ levels while CSGG induced immunosuppressive regulatory T cells and interleukin-10. These findings demonstrate that bacterial polysaccharides have a distinct role depending on their chemical structure in regulation of the host/bacterium interaction. Our findings suggest that polysaccharides may differentially regulate the host immunity depending on the composition of this complex mixture, either enhancing immunity or inducing immune tolerance
URI
https://pr.ibs.re.kr/handle/8788114/5960
ISSN
0144-8617
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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