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Neural circuits underlying a psychotherapeutic regimen for fear disorders

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Title
Neural circuits underlying a psychotherapeutic regimen for fear disorders
Author(s)
Jinhee Baek; Sukchan Lee; Taesup Cho; Seong-Wook Kim; Minsoo Kim; Yongwoo Yoon; Ko Keun Kim; Junweon Byun; Kim S.J.; Jeong J.; Hee-Sup Shin
Publication Date
2019-02
Journal
NATURE, v.566, no.7744, pp.339 - 343
Publisher
NATURE PUBLISHING GROUP
Abstract
A psychotherapeutic regimen that uses alternating bilateral sensory stimulation (ABS) has been used to treat post-traumatic stress disorder. However, the neural basis that underlies the long-lasting effect of this treatment—described as eye movement desensitization and reprocessing—has not been identified. Here we describe a neuronal pathway driven by the superior colliculus (SC) that mediates persistent attenuation of fear. We successfully induced a lasting reduction in fear in mice by pairing visual ABS with conditioned stimuli during fear extinction. Among the types of visual stimulation tested, ABS provided the strongest fear-reducing effect and yielded sustained increases in the activities of the SC and mediodorsal thalamus (MD). Optogenetic manipulation revealed that the SC–MD circuit was necessary and sufficient to prevent the return of fear. ABS suppressed the activity of fear-encoding cells and stabilized inhibitory neurotransmission in the basolateral amygdala through a feedforward inhibitory circuit from the MD. Together, these results reveal the neural circuit that underlies an effective strategy for sustainably attenuating traumatic memories. © 2019, The Author(s), under exclusive licence to Springer Nature Limited
URI
https://pr.ibs.re.kr/handle/8788114/5897
ISSN
0028-0836
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Social Neuroscience Group(사회성 뇌과학 그룹) > Journal Papers (저널논문)
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