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Strong host-guest interaction enables facile and controllable surface modification of cucurbit[6]uril-based polymer nanocapsules for in vivo cancer targeting

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Title
Strong host-guest interaction enables facile and controllable surface modification of cucurbit[6]uril-based polymer nanocapsules for in vivo cancer targeting
Author(s)
Kim S.; Moon Young Hur; Junghyun Kim; Kyeng Min Park; Kimoon Kim
Publication Date
2019-03
Journal
Supramolecular Chemistry, v.31, no.5, pp.289 - 295
Publisher
Taylor & Francis Online
Abstract
Cucurbit[6]uril-based polymer nanocapsules (CB[6]PNs), covalently conjugated with a near-infrared dye (Cy 7), was exploited as a stable platform (Cy7-CB[6]PNs) for in vivo cancer targeting. The strong host-guest interaction between CB[6] and spermidine (spmd) enabled us to modify the surface of the nanocapsules with spmd-conjugated cancer targeting functional tags in a facile, controllable and non-covalent manner. Thanks to the strong host-guest interaction retained even in the bloodstream of a mouse, enhanced accumulation of Cy7-CB[6]PNs on cancer tissues of mice was successfully detected via NIR imaging when the nanocapsules were treated with more number of the cancer targeting functional tags. This result showed the potential of the CB[6]-based strong host-guest interaction as a controllable and efficient tool for surface modification of in vivo cancer targeting nanomaterials. © 2019 Informa UK Limited, trading as Taylor & Francis Group
URI
https://pr.ibs.re.kr/handle/8788114/5816
ISSN
1061-0278
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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