Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial DevelopmentHighly Cited Paper
DC Field | Value | Language |
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dc.contributor.author | Lee Y.-S. | - |
dc.contributor.author | Kim T.-Y. | - |
dc.contributor.author | Kim Y. | - |
dc.contributor.author | Lee S.-H. | - |
dc.contributor.author | Kim S. | - |
dc.contributor.author | Kang S.W. | - |
dc.contributor.author | Yang J.-Y. | - |
dc.contributor.author | Baek I.-J. | - |
dc.contributor.author | Sung Y.H. | - |
dc.contributor.author | Park Y.-Y. | - |
dc.contributor.author | Hwang S.W. | - |
dc.contributor.author | Eunju O. | - |
dc.contributor.author | Kwangsoon Kim | - |
dc.contributor.author | Liu S. | - |
dc.contributor.author | Kamada N. | - |
dc.contributor.author | Gao N. | - |
dc.contributor.author | Kweon M.-N. | - |
dc.date.available | 2019-01-30T01:58:48Z | - |
dc.date.created | 2018-12-26 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/5384 | - |
dc.description.abstract | Symbionts play an indispensable role in gut homeostasis, but underlying mechanisms remain elusive. To clarify the role of lactic-acid-producing bacteria (LAB) on intestinal stem-cell (ISC)-mediated epithelial development, we fed mice with LAB-type symbionts such as Bifidobacterium and Lactobacillus spp. Here we show that administration of LAB-type symbionts significantly increased expansion of ISCs, Paneth cells, and goblet cells. Lactate stimulated ISC proliferation through Wnt/��-catenin signals of Paneth cells and intestinal stromal cells. Moreover, Lactobacillus plantarum strains lacking lactate dehydrogenase activity, which are deficient in lactate production, elicited less ISC proliferation. Pre-treatment with LAB-type symbionts or lactate protected mice in response to gut injury provoked by combined treatments with radiation and a chemotherapy drug. Impaired ISC-mediated epithelial development was found in mice deficient of the lactate G-protein-coupled receptor, Gpr81. Our results demonstrate that LAB-type symbiont-derived lactate plays a pivotal role in promoting ISC-mediated epithelial development in a Gpr81-dependent manner. Lee et al. reveal how lactic-acid-producing bacteria, including Bifidobacterium and Lactobacillus spp., support intestinal epithelial cell regeneration. Symbiont-derived lactate is sensed by G-protein-coupled receptor 81 on Paneth and stromal cells to promote regeneration in a Wnt3/ ��-catenin-dependent manner. Lactate pre-administration protects mice exposed to radiation- and chemotherapy-induced intestinal damage. ? 2018 Elsevier Inc | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.subject | Gpr81 | - |
dc.subject | gut microbiota | - |
dc.subject | intestinal stem cell | - |
dc.subject | lactate | - |
dc.subject | symbiont | - |
dc.title | Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000453027400010 | - |
dc.identifier.scopusid | 2-s2.0-85057565842 | - |
dc.identifier.rimsid | 66437 | - |
dc.contributor.affiliatedAuthor | Eunju O. | - |
dc.contributor.affiliatedAuthor | Kwangsoon Kim | - |
dc.identifier.doi | 10.1016/j.chom.2018.11.002 | - |
dc.identifier.bibliographicCitation | CELL HOST & MICROBE, v.24, no.6, pp.833 - 8.46E+08 | - |
dc.citation.title | CELL HOST & MICROBE | - |
dc.citation.volume | 24 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 833 | - |
dc.citation.endPage | 8.46E+08 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Gpr81 | - |
dc.subject.keywordAuthor | gut microbiota | - |
dc.subject.keywordAuthor | intestinal stem cell | - |
dc.subject.keywordAuthor | lactate | - |
dc.subject.keywordAuthor | symbiont | - |