Multichannel digital heteronuclear magnetic resonance biosensor

Cited 0 time in webofscience Cited 0 time in scopus
35 Viewed 28 Downloaded
Title
Multichannel digital heteronuclear magnetic resonance biosensor
Author(s)
Stephan Huber; Changwook Min; Christoph Staat; Juhyun Oh; Cesar M. Castro; Axel Haase; Ralph Weissleder; Bernhard Gleich; Hakho Lee
Publication Date
2019-02
Journal
BIOSENSORS & BIOELECTRONICS, v.126, no., pp.240 - 248
Publisher
ELSEVIER ADVANCED TECHNOLOGY
Abstract
Low-field, mobile NMR systems are increasingly used across diverse fields, including medical diagnostics, food quality control, and forensics. The throughput and functionality of these systems, however, are limited due to their conventional single-channel detection: one NMR probe exclusively uses an NMR console at any given time. Under this design, multi-channel detection could only be accomplished by either serially accessing individual probes or stacking up multiple copies of NMR electronics; this approach still retains limitations such as long assay times and increased system complexity. Here we present a new scalable architecture, HERMES (hetero-nuclear resonance multichannel electronic system), for versatile, high-throughput NMR analyses. HERMES exploits the concept of software-defined radio by virtualizing NMR electronics in the digital domain. This strategy i) creates multiple NMR consoles without adding extra hardware; ii) acquires signals from multiple NMR channels in parallel; and iii) operates in wide frequency ranges. All of these functions could be realized on-demand in a single compact device. We interfaced HERMES with an array of NMR probes; the combined system simultaneously measured NMR relaxation from multiple samples and resolved spectra of hetero-nuclear spins (1H, 19F, 13C). For potential diagnostic uses, we applied the system to detect dengue fever and molecularly profile cancer cells through multi-channel protein assays. HERMES holds promise as a powerful analytical tool that enables rapid, reconfigurable, and parallel detection. © 2018 Elsevier B.V
URI
https://pr.ibs.re.kr/handle/8788114/5337
ISSN
0956-5663
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > Journal Papers
Files in This Item:
201902_Biosensors and Bioelectronics_Multichannel digital heteronuclear magnetic resonance biosensor.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse