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유전체 항상성 연구단
유전체 항상성 연구단
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Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells

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Title
Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells
Author(s)
Hanho Shin; Ji Hye Han; Juhwan Yoon; Hyo Jung Sim; Tae Joo Park; Siyoung Yang; Eun Kyung Lee; Rohit N. Kulkarni; Josephine M. Egan; Wook Kim
Publication Date
2018-02
Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.22, no.4, pp.2337 - 2345
Publisher
WILEY
Abstract
Cannabinoid 1 receptors (CB1Rs) are expressed in peripheral tissues, including islets of Langerhans, where their function(s) is under scrutiny. Using mouse beta-cell lines, human islets and CB1R-null (CB1R(-/-)) mice, we have now investigated the role of CB1Rs in modulating beta-cell function and glucose responsiveness. Synthetic CB1R agonists diminished GLP-1-mediated cAMP accumulation and insulin secretion as well as glucose-stimulated insulin secretion in mouse beta-cell lines and human islets. In addition, silencing CB1R in mouse cells resulted in an increased expression of pro-insulin, glucokinase (GCK) and glucose transporter 2 (GLUT2), but this increase was lost in cells lacking insulin receptor. Furthermore, CB1R(-/-) mice had increased pro-insulin, GCK and GLUT2 expression in cells. Our results suggest that CB1R signalling in pancreatic islets may be harnessed to improve beta-cell glucose responsiveness and preserve their function. Thus, our findings further support that blocking peripheral CB1Rs would be beneficial to beta-cell function in type 2 diabetes. © 2018 The Authors.
URI
http://pr.ibs.re.kr/handle/8788114/5300
ISSN
1582-4934
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > Journal Papers (저널논문)
Files in This Item:
2018_J Cell. Mol. Med._Blockade of cannabinoid 1 receptor improves glucoseresponsiveness in pancreatic beta cells.pdfDownload

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