BROWSE

Related Scientist

kim,seonggi's photo.

kim,seonggi
뇌과학이미징연구단
more info

ITEM VIEW & DOWNLOAD

Chemical exchange-sensitive spin-lock MRI of glucose analog 3-O-methyl-D-glucose in normal and ischemic brain

Cited 7 time in webofscience Cited 13 time in scopus
819 Viewed 199 Downloaded
Title
Chemical exchange-sensitive spin-lock MRI of glucose analog 3-O-methyl-D-glucose in normal and ischemic brain
Author(s)
Tao Jin; Hunter Mehrens; Ping Wang; Seong-Gi Kim
Subject
Brain imaging, CEST, glucose, 2-deoxyglucose, acute stroke
Publication Date
2018-05
Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.38, no.5, pp.869 - 880
Publisher
SAGE PUBLICATIONS INC
Abstract
Glucose transport is important for understanding brain glucose metabolism. We studied glucose transport with a presumably non-toxic and non-metabolizable glucose analog, 3-O-methyl-d-glucose, using a chemical exchange-sensitive spin-lock MRI technique at 9.4 Tesla. 3-O-methyl-d-glucose showed comparable chemical exchange properties with d-glucose and 2-deoxy-d-glucose in phantoms, and higher and lower chemical exchange-sensitive spin-lock sensitivity than Glc and 2-deoxy-d-glucose in in vivo experiments, respectively. The changes of the spin-lattice relaxation rate in the rotating frame (ΔR1ρ) in normal rat brain peaked at ∼15 min after the intravenous injection of 1 g/kg 3-O-methyl-d-glucose and almost maintained a plateau for >1 h. Doses up to 4 g/kg 3-O-methyl-d-glucose were linearly correlated with ΔR1ρ. In rats with focal ischemic stroke, chemical exchange-sensitive spin-lock with 3-O-methyl-d-glucose injection at 1 h after stroke onset showed reduced ΔR1ρ in the ischemic core but higher ΔR1ρ in the peri-core region compared to normal tissue, which progressed into the ischemic core at 3 h after stroke onset. This suggests that the hyper-chemical exchange-sensitive spin-lock region observed at 1 h is the ischemic penumbra at-risk of infarct. In summary, 3-O-methyl-d-glucose-chemical exchange-sensitive spin-lock can be a sensitive MRI technique to probe the glucose transport in normal and ischemic brains.(Journal of Cerebral Blood Flow & Metabolism 2018) (c) Author(s) 2017
URI
https://pr.ibs.re.kr/handle/8788114/5277
DOI
10.1177/0271678X17707419
ISSN
0271-678X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
Chemical exchange-sensitive spin-lock MRI of glucose analog 3-O-methyl-D-glucose in normal and ischemic brain_김성기.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse