Chemical exchange-sensitive spin-lock MRI of glucose analog 3-O-methyl-D-glucose in normal and ischemic brain

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Title
Chemical exchange-sensitive spin-lock MRI of glucose analog 3-O-methyl-D-glucose in normal and ischemic brain
Author(s)
Tao Jin; Hunter Mehrens; Ping Wang; Seong-Gi Kim
Publication Date
2018-05
Journal
Journal of Cerebral Blood Flow and Metabolism, v.38, no.5, pp.869 - 880
Publisher
SAGE PUBLICATIONS INC
Abstract
Glucose transport is important for understanding brain glucose metabolism. We studied glucose transport with a presumably non-toxic and non-metabolizable glucose analog, 3-O-methyl-d-glucose, using a chemical exchange-sensitive spin-lock MRI technique at 9.4 Tesla. 3-O-methyl-d-glucose showed comparable chemical exchange properties with d-glucose and 2-deoxy-d-glucose in phantoms, and higher and lower chemical exchange-sensitive spin-lock sensitivity than Glc and 2-deoxy-d-glucose in in vivo experiments, respectively. The changes of the spin-lattice relaxation rate in the rotating frame (ΔR1ρ) in normal rat brain peaked at ∼15 min after the intravenous injection of 1 g/kg 3-O-methyl-d-glucose and almost maintained a plateau for >1 h. Doses up to 4 g/kg 3-O-methyl-d-glucose were linearly correlated with ΔR1ρ. In rats with focal ischemic stroke, chemical exchange-sensitive spin-lock with 3-O-methyl-d-glucose injection at 1 h after stroke onset showed reduced ΔR1ρ in the ischemic core but higher ΔR1ρ in the peri-core region compared to normal tissue, which progressed into the ischemic core at 3 h after stroke onset. This suggests that the hyper-chemical exchange-sensitive spin-lock region observed at 1 h is the ischemic penumbra at-risk of infarct. In summary, 3-O-methyl-d-glucose-chemical exchange-sensitive spin-lock can be a sensitive MRI technique to probe the glucose transport in normal and ischemic brains.(Journal of Cerebral Blood Flow & Metabolism 2018) (c) Author(s) 2017
URI
https://pr.ibs.re.kr/handle/8788114/5277
ISSN
0271-678X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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