Biophysics of BOLD fMRI Investigated with Animal Models

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Title
Biophysics of BOLD fMRI Investigated with Animal Models
Author(s)
Seong-Gi Kim
Publication Date
2018-07
Journal
JOURNAL OF MAGNETIC RESONANCE, v.292, no., pp.82 - 89
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Abstract
The widely-used BOLD fMRI signal depends on various anatomical, physiological, and imaging parameters. Thus, it is important to examine its biophysical and physiological source in order to optimize, model and accurately interpret fMRI. Animal models have been used to investigate these issues to take systematic measurements and combine with conventional invasive approaches. Here, we reviewed and discussed multiple issues, including the echo time-dependent intravascular contribution and extravascular contributions, gradient-echo vs. spin-echo fMRI, the physiological source of BOLD fMRI, arterial vs. venous cerebral blood volume change, cerebral oxygen consumption change, and arterial oxygen saturation change. We then discuss future directions of animal fMRI and translation to human fMRI. Systematic biophysical BOLD fMRI studies provide insight into the modeling and interpretation of BOLD fMRI in animals and humans.(c)2018 Elsevier Inc. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/5259
ISSN
1090-7807
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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