The role of striatal G alpha(q/11) protein in methamphetamine-induced behavioral sensitization in mice

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Title
The role of striatal G alpha(q/11) protein in methamphetamine-induced behavioral sensitization in mice
Author(s)
Kwang-Wook Lee; Kyungin Kim; Hyoung-Chun Kim; Seok-Yong Lee; Choon-Gon Jang
Publication Date
2018-07
Journal
BEHAVIOURAL BRAIN RESEARCH, v.346, no., pp.66 - 72
Publisher
ELSEVIER SCIENCE BV
Abstract
G alpha(q/11) protein transducer signals from neurotransmitter receptors and has been implicated in several functions of the central nervous system. In this study, the role of G alpha(q/11) protein in methamphetamine (METH)-induced behavioral sensitization was investigated using neurochemical and behavioral approaches. Repeated treatment with METH (2 mg/kg, intraperitoneally) significantly increased behavioral sensitization as well as G alpha(q/11) protein expression and G alpha protein activity in the striata of mice, while a single treatment of METH at the same dose did not affect these parameters. Repeated intrastriatal injections of a G alpha(q/11) inhibitor, [D-Trp7,9,10]-substance P, significantly reduced behavioral sensitization and striatal dopamine (DA) level in response to METH, with no effect on striatal tyrosine hydroxylase expression. These results suggest that G alpha(q/11) protein facilitates METH-induced behavioral sensitization by modulating DA release in the mouse striatum © 2017 Elsevier B.V. All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/5258
ISSN
0166-4328
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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