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The role of striatal G alpha(q/11) protein in methamphetamine-induced behavioral sensitization in mice

DC Field Value Language
dc.contributor.authorKwang-Wook Lee-
dc.contributor.authorKyungin Kim-
dc.contributor.authorHyoung-Chun Kim-
dc.contributor.authorSeok-Yong Lee-
dc.contributor.authorChoon-Gon Jang-
dc.date.available2019-01-03T05:33:46Z-
dc.date.created2018-06-12-
dc.date.issued2018-07-
dc.identifier.issn0166-4328-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/5258-
dc.description.abstractG alpha(q/11) protein transducer signals from neurotransmitter receptors and has been implicated in several functions of the central nervous system. In this study, the role of G alpha(q/11) protein in methamphetamine (METH)-induced behavioral sensitization was investigated using neurochemical and behavioral approaches. Repeated treatment with METH (2 mg/kg, intraperitoneally) significantly increased behavioral sensitization as well as G alpha(q/11) protein expression and G alpha protein activity in the striata of mice, while a single treatment of METH at the same dose did not affect these parameters. Repeated intrastriatal injections of a G alpha(q/11) inhibitor, [D-Trp7,9,10]-substance P, significantly reduced behavioral sensitization and striatal dopamine (DA) level in response to METH, with no effect on striatal tyrosine hydroxylase expression. These results suggest that G alpha(q/11) protein facilitates METH-induced behavioral sensitization by modulating DA release in the mouse striatum © 2017 Elsevier B.V. All rights reserved-
dc.description.uri1-
dc.language영어-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectG alpha(q/11) protein-
dc.subjectMethamphetamine-
dc.subjectBehavioral sensitization-
dc.subjectDopamine-
dc.subject[S-35]GTPGTP gamma S binding level-
dc.subjectIn vivo microdialysis-
dc.titleThe role of striatal G alpha(q/11) protein in methamphetamine-induced behavioral sensitization in mice-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000430645500008-
dc.identifier.scopusid2-s2.0-85037550248-
dc.identifier.rimsid63495-
dc.contributor.affiliatedAuthorKwang-Wook Lee-
dc.identifier.doi10.1016/j.bbr.2017.12.003-
dc.identifier.bibliographicCitationBEHAVIOURAL BRAIN RESEARCH, v.346, pp.66 - 72-
dc.citation.titleBEHAVIOURAL BRAIN RESEARCH-
dc.citation.volume346-
dc.citation.startPage66-
dc.citation.endPage72-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusMEDIATED DOPAMINE RELEASE-
dc.subject.keywordPlusMESSENGER-RNAS-
dc.subject.keywordPlusNOREPINEPHRINE TRANSPORTER-
dc.subject.keywordPlusPC12 CELLS-
dc.subject.keywordPlusKINASE-C-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusAMPHETAMINE-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusPHARMACOLOGY-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordAuthorG alpha(q/11) protein-
dc.subject.keywordAuthorMethamphetamine-
dc.subject.keywordAuthorBehavioral sensitization-
dc.subject.keywordAuthorDopamine-
dc.subject.keywordAuthor[S-35]GTPGTP gamma S binding level-
dc.subject.keywordAuthorIn vivo microdialysis-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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