BROWSE

Related Scientist

lee,boyong's photo.

lee,boyong
인지및사회성연구단
more info

ITEM VIEW & DOWNLOAD

The Possible Role of Neurobeachin in Extinction of Contextual Fear Memory

Cited 1 time in webofscience Cited 1 time in scopus
1,098 Viewed 601 Downloaded
Title
The Possible Role of Neurobeachin in Extinction of Contextual Fear Memory
Author(s)
Boyoung Lee; Eunyoung Bang; Won Suk Yang; Afshin Paydar; Go Eun Ha; Sujin Kim; Jong-Hyun Kim; Taesuo Cho; Seung Eun Lee; Sukchan Lee; Myung-Goo Kang; Eunji Cheong; Key-Sun Kim; Cheolju Lee; Myeong-Hee Yu; Hee-Sup Shin
Publication Date
2018-09
Journal
SCIENTIFIC REPORTS, v.8, no.1, pp.13752
Publisher
NATURE PUBLISHING GROUP
Abstract
Established fear memory becomes vulnerable to disruption after memory retrieval and extinction; this labile state is critical for inhibiting the return of fear memory. However, the labile state has a very narrow time window after retrieval, and underlying molecular mechanisms are not well known. To that end, we isolated the hippocampus immediately after fear memory retrieval and performed proteomics. We identified Neurobeachin (NBEA), an autism-related regulator of synaptic protein trafficking, to be upregulated after contextual fear memory retrieval. NBEA protein expression was rapid and transient after fear memory retrieval at the synapse. Nbea mRNA was enriched at the synapses, and the rapid induction of NBEA expression was blocked by inhibition of the mammalian target of rapamycin (mTOR)-dependent signaling pathway. Mice with cornu ammonis 1 (CA1)-specific Nbea shRNA knockdown showed normal fear acquisition and contextual fear memory but impaired extinction, suggesting an important role of Nbea in fear memory extinction processes. Consistently, Nbea heterozygotes showed normal fear acquisition and fear memory recall but showed impairment in extinction. Our data suggest that NBEA is necessary either for induction of memory lability or for the physiological process of memory extinction. © The Author(s) 2018
URI
https://pr.ibs.re.kr/handle/8788114/5169
DOI
10.1038/s41598-018-30589-1
ISSN
2045-2322
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Social Neuroscience Group(사회성 뇌과학 그룹) > 1. Journal Papers (저널논문)
Files in This Item:
The Possible Role of Neurobeachin in Extinction of Contextual Fear Memory.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse